对麻风杆菌有反应性的人T细胞克隆作为表征潜在麻风疫苗的工具。
Human T-cell clones with reactivity to Mycobacterium leprae as tools for the characterization of potential vaccines against leprosy.
作者信息
Emmrich F, Kaufmann S H
出版信息
Infect Immun. 1986 Mar;51(3):879-83. doi: 10.1128/iai.51.3.879-883.1986.
Abstract
T-cell clones with the T4 phenotype were established from patients with tuberculoid leprosy. The antigen reactivity of these clones ranged from stringent specificity for Mycobacterium leprae to broad cross-reactivity with other mycobacteria. Killed M. leprae had a weak stimulatory capacity which could be enhanced by ultrasonication. Among the three candidate antileprosy vaccines, M. leprae, M. bovis BCG, and the ICRC (Indian Cancer Research Center) strain, the last was superior in stimulating cross-reactive T4 clones. This finding argues for a differential masking of similar or identical membrane antigens in various mycobacterial species. T-cell clones with defined reactivity patterns for mycobacterial antigens could be helpful tools for the characterization of an antileprosy vaccine.
摘要
从结核样型麻风患者中建立了具有T4表型的T细胞克隆。这些克隆的抗原反应性范围从对麻风分枝杆菌的严格特异性到与其他分枝杆菌的广泛交叉反应性。灭活的麻风分枝杆菌具有较弱的刺激能力，超声处理可增强这种能力。在三种候选抗麻风疫苗（麻风分枝杆菌、牛型结核分枝杆菌卡介苗和印度癌症研究中心菌株）中，最后一种在刺激交叉反应性T4克隆方面表现更优。这一发现表明不同分枝杆菌物种中相似或相同的膜抗原存在差异性掩盖。具有明确分枝杆菌抗原反应模式的T细胞克隆可能是鉴定抗麻风疫苗的有用工具。
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