表达乙型肝炎病毒表面抗原的感染性痘苗病毒重组体。
Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen.
作者信息
Smith G L, Mackett M, Moss B
出版信息
Nature. 1983 Apr 7;302(5908):490-5. doi: 10.1038/302490a0.
DOI:10.1038/302490a0
PMID:6835382
Abstract
Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.
摘要
已经生产出了针对乙型肝炎病毒的潜在活疫苗。乙型肝炎病毒表面抗原（HBsAg）的编码序列已在痘苗病毒早期启动子的控制下插入痘苗病毒基因组。感染这些痘苗病毒重组体的细胞合成并分泌HBsAg，接种疫苗的兔子能迅速产生针对HBsAg的抗体。
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