麻风病中γ干扰素产生缺陷。抗原和白细胞介素2可使其恢复。
Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2.
作者信息
Nogueira N, Kaplan G, Levy E, Sarno E N, Kushner P, Granelli-Piperno A, Vieira L, Colomer Gould V, Levis W, Steinman R
出版信息
J Exp Med. 1983 Dec 1;158(6):2165-70. doi: 10.1084/jem.158.6.2165.
Abstract
Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.
摘要
对34例麻风病患者外周血单个核细胞中抗原和丝裂原诱导的γ干扰素（γ-IFN）产生情况进行了研究。18例瘤型麻风及界线类偏瘤型患者（LL和BL）中有17例对特异性抗原（麻风分枝杆菌）无γ-IFN释放反应，对丝裂原（刀豆球蛋白A）刺激的反应也降低。相比之下，6例结核样型和界线类偏结核样型患者（TT和BT）的细胞在相同实验条件下产生了相当水平的γ-IFN。正常对照对麻风分枝杆菌无反应，大多数对刀豆球蛋白A反应良好。中间界线类患者（BB）的γ-IFN释放水平处于中间状态。瘤型患者的γ-IFN释放可通过纯化的白细胞介素2和麻风分枝杆菌抗原部分恢复，但单独使用白细胞介素2则不能。
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