Ansari Mohammad Hassan Khadem, Gholamnejad Mahdia, Meghrazi Khadije, Khalkhali Hamid Reza
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Pulmonology Department, Urmia University of Medical Sciences, Urmia, Iran.
Med J Islam Repub Iran. 2018 Dec 29;32:133. doi: 10.14196/mjiri.32.133. eCollection 2018.
Omentin has recently been considered as an adipokine secreted from visceral fat and is expressed in the lungs, heart, ovary etc. Various studies have shown that omentin may have an anti-inflammatory role in the inflammatory process and the amount of omentin alters in some cancers, such as colorectal, prostate and renal cells cancers, changes. The serum level of omentin, however, remains unknown in non-patient smokers and the smokers afflicted with lung cancer. Therefore, this study examines the serum levels of omentin in smokers suffering from lung cancer. The amount of serum omentin was measured in 45 patients with lung cancer and 61 age - and sex - matched controls (30 smokers and 31 non-smokers) using enzyme-linked immunosorbent assay (ELISA) kit. Data were analyzed using SPSS-16, and oneway analysis of variance and Scheffe post hoc test were used to determine and compare the serum levels of omentin in different types of lung malignancies. Significance level was set at p≤0.05. The amount of circulating omentin for healthy non-smokers and non-patient smokers was 3.55±0.57 ng/l and 5.43±1.95 ng/l, respectively (p<0.001). The serum level of omentin was 3.63±0.70 ng/l for smokers afflicted with cancer (p<0.001 compared with nonpatient smokers: 5.43±1.95). The meaningful decrease in omentin levels in smokers with lung cancer can be considered as a risk factor in smokers and can use as a significant factor in the prognosis of lung cancer in these people.
网膜素最近被认为是一种由内脏脂肪分泌的脂肪因子，在肺、心脏、卵巢等组织中表达。各种研究表明，网膜素可能在炎症过程中发挥抗炎作用，并且在某些癌症（如结直肠癌、前列腺癌和肾细胞癌）中网膜素的含量会发生变化。然而，非患病吸烟者和患肺癌吸烟者的血清网膜素水平尚不清楚。因此，本研究检测了患肺癌吸烟者的血清网膜素水平。使用酶联免疫吸附测定（ELISA）试剂盒测量了45例肺癌患者和61例年龄及性别匹配的对照者（30名吸烟者和31名非吸烟者）的血清网膜素含量。数据采用SPSS-16进行分析，单因素方差分析和谢弗事后检验用于确定和比较不同类型肺恶性肿瘤患者的血清网膜素水平。显著性水平设定为p≤0.05。健康非吸烟者和非患病吸烟者的循环网膜素含量分别为3.55±0.57 ng/l和5.43±1.95 ng/l（p<0.001）。患癌症吸烟者的血清网膜素水平为3.63±0.70 ng/l（与非患病吸烟者5.43±1.95相比，p<0.001）。肺癌吸烟者网膜素水平的显著降低可被视为吸烟者的一个危险因素，并可作为这些人肺癌预后的一个重要因素。
