Lewandowski Krzysztof, Nadel Iwona, Lewinski Andrzej, Bienkiewicz Małgorzata, Tan B, Randeva Harpal S, Cypryk Katarzyna
Department of Endocrinology & Metabolic Diseases, Medical University of Lodz, Poland.
Ginekol Pol. 2010 Dec;81(12):907-12.
Gestational Diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression.
The study included 20 women with GDM, diagnosed according to the WHO criteria, and 23 matched for age and BMI women with normal glucose tolerance. Omentin and TSP-1 were measured by ELISA assays. Insulin resistance was assessed by HOMA and Insulin Resistance Index (IRI).
There were no significant differences in omentin and TSP-1 levels between subjects with GDM and controls (48.0 +/- 12.0 ng/ml versus 50.2 +/- 7.9 ng/ml and 2150 +/- 1661 ng/ml versus 1569 +/- 1160 ng/ml, p = 0.64 and p = 0.29, for omentin and TSP-1 in GDM and control subjects, respectively). There was no significant correlation between either omentin or TSP-1 with HOMA or IRI, however there was a significant positive correlation between thrombospondin-1 and omentin (r = 0.49, p = 0.010). There was also a positive correlation between serum omentin and glucose levels at 60 and 90 minutes of OGTT, however, in the control group only (p < 0.05).
Concentrations of omentin and thrombospondin-1 seem to be inter-related in pregnancy however there are no differences in serum levels between women with normal glucose tolerance and those with glucose intolerance. These observations suggest that regulation of concentrations of these adipokines in pregnancy might be mediated though different mechanisms than in non-pregnant subjects.
妊娠期糖尿病（GDM）的特征是胰岛素抵抗和促炎状态，这两个因素都可能与脂肪因子表达有关。
本研究纳入了20例根据世界卫生组织标准诊断的GDM女性，以及23例年龄和体重指数相匹配的糖耐量正常女性。通过酶联免疫吸附测定法检测网膜素和血小板反应蛋白-1（TSP-1）。通过稳态模型评估法（HOMA）和胰岛素抵抗指数（IRI）评估胰岛素抵抗。
GDM患者与对照组之间的网膜素和TSP-1水平无显著差异（GDM组和对照组的网膜素分别为48.0±12.0 ng/ml和50.2±7.9 ng/ml，TSP-1分别为2150±1661 ng/ml和1569±1160 ng/ml，网膜素和TSP-1的p值分别为0.64和0.29）。网膜素或TSP-1与HOMA或IRI之间均无显著相关性，然而血小板反应蛋白-1与网膜素之间存在显著正相关（r = 0.49，p = 0.010）。血清网膜素与口服葡萄糖耐量试验（OGTT）60分钟和90分钟时的血糖水平之间也存在正相关，但仅在对照组中（p < 0.05）。
妊娠期网膜素和血小板反应蛋白-1的浓度似乎相互关联，然而糖耐量正常女性与糖耐量异常女性的血清水平并无差异。这些观察结果表明，妊娠期这些脂肪因子浓度的调节可能通过与非妊娠受试者不同的机制介导。
