一种新型的基于吲哚菁绿的肝脏特异性荧光抗癌药物输送系统。
A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green.
机构信息
Hepato-Biliary-Pancreatic Surgery Division and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Laboratory of Chemical Biology & Molecular Imaging, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
Sci Rep. 2019 Feb 28;9(1):3044. doi: 10.1038/s41598-019-39269-0.
Indocyanine green (ICG) accumulates only in hepatocytes and their malignant counterpart, hepatocellular carcinoma (HCC). We have developed ICG-conjugated anti-cancer drugs and noted their significant accumulation in HCC cells both in vitro and in vivo. ICG-conjugated gemcitabine was less toxic to normal cells and it had superior anti-tumor action compared to gemcitabine alone in a subcutaneous tumor xenograft. ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC.
靛氰绿（ICG）仅在肝细胞及其恶性对应物肝癌（HCC）中积累。我们已经开发了 ICG 结合的抗癌药物，并注意到它们在体外和体内均在 HCC 细胞中大量积累。与单独使用吉西他滨相比，ICG 结合的吉西他滨对正常细胞的毒性较小，并且在皮下肿瘤异种移植中具有更好的抗肿瘤作用。ICG 缀合可以为治疗肝癌提供一种新的荧光药物递送系统，该系统可用于 HCC 的诊断和治疗。
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