Department of Biomaterials, University of Gothenburg, Gothenburg, Sweden.
Department of Prosthodontics, University of Malmö, Malmö, Sweden.
Clin Implant Dent Relat Res. 2019 Mar;21 Suppl 1:4-7. doi: 10.1111/cid.12742. Epub 2019 Feb 28.
The understanding of mechanisms of osseointegration as well as applied knowledge about oral implant surfaces are of paramount importance for successful clinical results.
The aim of the present article is to present an overview of osseointegration mechanisms and an introduction to surface innovations with relevance for osseointegration that will be published in the same supplement of Clinical Implant Dentistry and Related Research.
The present article is a narrative review of some osseointegration and implant surface-related details.
Osseointegration has a changed definition since it is realized today that oral implants are but foreign bodies and that this fact explains osseointegration as a protection mechanism of the tissues. Given adequate stability, bone tissue is formed around titanium implants to shield them from the tissues. Oral implant surfaces may be characterized by microroughness and nanoroughness, by surface chemical composition and by physical and mechanical parameters. An isotropic, moderately rough implant surface such as seen on the TiUnite device has displayed improved clinical results compared to previously used minimally rough or rough surfaces. However, there is a lack of clinical evidence supporting any particular type of nanoroughness pattern that, at best, is documented with results from animal studies. It is possible, but as yet unproven, that clinical results may be supported by a certain chemical composition of the implant surface. The same can be said with respect to hydrophilicity of implant surfaces; positive animal data may suggest some promise, but there is a lack of clinical evidence that hydrophilic implants result in improved clinical outcome of more hydrophobic surfaces. With respect to mechanical properties, it seems obvious that those must be encompassing the loading of oral implants, but we need more research on the mechanically ideal implant surface from a clinical aspect.
理解骨整合机制以及口腔种植体表面的应用知识对于获得成功的临床效果至关重要。
本文旨在介绍骨整合机制概述以及与骨整合相关的表面创新介绍,这些内容将在同一期《临床植入牙科与相关研究》增刊中发表。
本文是对一些骨整合和种植体表面相关细节的叙述性综述。
骨整合的定义已经发生了变化,因为人们现在意识到口腔种植体只是异物,这一事实解释了骨整合作为组织保护机制的原因。在足够的稳定性下,钛种植体周围会形成骨组织,将其与组织隔离开来。口腔种植体表面的特征可以是微观粗糙度和纳米粗糙度、表面化学成分以及物理和机械参数。具有各向同性、适度粗糙表面的种植体,如 TiUnite 设备上的表面,与以前使用的微粗糙或粗糙表面相比,显示出更好的临床效果。然而,缺乏支持任何特定类型纳米粗糙度模式的临床证据,最好的情况是,只有动物研究的结果可以证明这一点。种植体表面的化学成分可能支持临床结果,但这还没有得到证实。种植体表面的亲水性也是如此;动物研究的积极数据可能表明有一定的前景,但缺乏临床证据表明亲水种植体能改善疏水性表面的临床效果。就机械性能而言,似乎很明显,这些性能必须包括口腔种植体的负载,但我们还需要从临床角度研究更理想的机械种植体表面。