Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA.
Med Sci Sports Exerc. 2019 Aug;51(8):1684-1691. doi: 10.1249/MSS.0000000000001952.
Identifying promoters of cerebral small vein integrity is important to counter vascular contributions to cognitive impairment and dementia.
In this preliminary investigation, the effects of a randomized 24-month physical activity (PA) intervention on changes in cerebral small vein integrity were compared to those of a health education (HE) control.
Cerebral small vein integrity was measured in 24 older adults (n = 8, PA; n = 16, HE) using ultra-high field MRI before and at the end of the 24-month intervention. Deep medullary veins were defined as straight or tortuous; percent change in straight length, tortuous length, and tortuosity ratio were computed. Microbleed count and white matter hyperintensities were also rated.
Accelerometry-based values of PA increased by 17.2% in the PA group but declined by 28.0% in the HE group. The PA group, but not the HE group, had a significant increase in straight vein length from baseline to 24-month follow-up (P = 0.02 and P = 0.21, respectively); the between-group difference in percent change in straight length was significant (increase: median, 93.6%; interquartile range, 112.9 for PA; median, 28.4%; interquartile range, 90.6 for HE; P = 0.07). Between group differences in other markers were nonsignificant.
Increasing PA in late-life may promote cerebral small vein integrity. This should be confirmed in larger studies.
识别脑小静脉完整性的促进因素对于对抗血管对认知障碍和痴呆的贡献非常重要。
在这项初步研究中，比较了随机 24 个月的体力活动（PA）干预对脑小静脉完整性变化的影响与健康教育（HE）对照组的影响。
在 24 名老年人（PA 组 n=8，HE 组 n=16）中使用超高场 MRI 在干预前和 24 个月后测量脑小静脉完整性。深髓静脉被定义为直或扭曲；计算直长度、扭曲长度和扭曲比的百分比变化。还对微出血计数和脑白质高信号进行了评分。
PA 组的加速度计测量的 PA 值增加了 17.2%，而 HE 组则下降了 28.0%。PA 组，而不是 HE 组，从基线到 24 个月随访有明显的直静脉长度增加（P=0.02 和 P=0.21）；直长度百分比变化的组间差异具有显著性（增加：中位数，93.6%；四分位距，112.9 为 PA；中位数，28.4%；四分位距，90.6 为 HE；P=0.07）。其他标志物的组间差异无统计学意义。
在生命后期增加 PA 可能会促进脑小静脉的完整性。这应在更大的研究中得到证实。
