Department of Therapeutic Radiology and Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, United States.
Department of Therapeutic Radiology and Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, United States.
DNA Repair (Amst). 2019 Apr;76:60-69. doi: 10.1016/j.dnarep.2019.02.006. Epub 2019 Feb 18.
Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS can saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted for oxidative modifications, including DNA and protein. The oxidation of DNA, which leads to base modification and formation of abasic sites along with single and double strand breaks, has been extensively investigated. Protein oxidation is often neglected and is only recently being recognized as an important regulatory mechanism of various DNA repair proteins. This is a review of the current state of research on the regulation of DNA repair by protein oxidation with emphasis on the correlation between inflammation and cancer.
活性氧和氮物种（RONS）是许多内源性细胞过程、感染反应和各种环境因素暴露的副产物。RONS 的增加会使抗氧化系统饱和，导致氧化应激。因此，大分子成为氧化修饰的目标，包括 DNA 和蛋白质。DNA 的氧化导致碱基修饰和无碱基位点的形成，以及单链和双链断裂，已经得到了广泛的研究。蛋白质氧化通常被忽视，直到最近才被认为是各种 DNA 修复蛋白的重要调节机制。这是一篇关于蛋白质氧化调节 DNA 修复的研究现状的综述，重点是炎症和癌症之间的相关性。
