Department of Neurology, University of Ioannina, University Hospital of Ioannina, Ioannina, 45110, Greece.
Department of Psychiatry, University of Ioannina, University Hospital of Ioannina, Ioannina, 45110, Greece.
Seizure. 2019 Mar;66:93-98. doi: 10.1016/j.seizure.2019.02.012. Epub 2019 Feb 20.
The purpose of the present study was to compare depression and QoL between patients with epilepsy and healthy controls, evaluating potentially related factors to depression and QoL in patients with epilepsy in Northwest Greece.
A case study was conducted in adult patients with epilepsy followed up at the University Hospital of Ioannina and in healthy controls. The Patient Health Questionnaire (PHQ-9) for depression's severity evaluation, the WHOQOL-BREF questionnaire for the QoL estimation and the Adverse Event Profile (AEP) questionnaire for the Antiepileptic Drugs (AEDs) adverse effects assessment were used.
Seventy patients with epilepsy and 70 controls were recruited. The PHQ-9 score was higher in patients compared to controls and slightly higher than reported in patients with epilepsy. PHQ-9 was significantly associated with the AEP score. Our patients had a poorer QoL compared to controls. The level of education, the AEP and the PHQ-9 scores were associated to QoL, the last two being the most powerful predictors of QoL.
Patients with epilepsy in Northwest Greece had higher rates of depression than reported in patients with epilepsy and poorer QoL compared to controls. The adverse effects of AEDs were related to depression in our study, while the adverse effects of AEDs and depression were more powerful predictors of QoL compared to demographics and other characteristics of epilepsy.
本研究旨在比较癫痫患者与健康对照者之间的抑郁和生活质量（QoL），评估希腊西北部癫痫患者中与抑郁和 QoL 相关的潜在因素。
在伊奥尼亚纳大学医院对接受随访的成年癫痫患者和健康对照者进行病例研究。采用患者健康问卷（PHQ-9）评估抑郁严重程度、世界卫生组织生活质量量表简表（WHOQOL-BREF）评估 QoL、不良事件概况量表（AEP）评估抗癫痫药物（AED）不良反应。
共纳入 70 例癫痫患者和 70 例对照者。与对照者相比，患者的 PHQ-9 评分更高，略高于已报道的癫痫患者中的评分。PHQ-9 与 AEP 评分显著相关。与对照者相比，我们的患者 QoL 更差。教育程度、AEP 和 PHQ-9 评分与 QoL 相关，后两者是 QoL 的最强预测因子。
与已报道的癫痫患者相比，希腊西北部的癫痫患者抑郁发生率更高，与对照者相比 QoL 更差。在本研究中，AED 的不良反应与抑郁相关，而与人口统计学和癫痫其他特征相比，AED 的不良反应和抑郁是 QoL 的更强预测因子。
