1Department of Neurology, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Referral Centre of the Ministry of Health of the Republic of Croatia for Epilepsy, Affiliated Partner of the ERN EpiCARE, Zagreb, Croatia; 2Department of Neurosurgery, Zagreb University Hospital Centre, School of Medicine, University of Zagreb, Affiliated Partner of EUROCAN, Zagreb, Croatia; 3Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia; 4Klinički studio, Private Psychology Practice, Zagreb, Croatia; 5Istrian Health Centre, Umag Section, Umag, Croatia; 6Department of Neurology, Dubrava University Hospital, School of Medicine, University of Zagreb, Zagreb, Croatia; 7Sveti Ivan Psychiatric Hospital, Zagreb, Croatia.
Acta Clin Croat. 2021 Dec;60(Suppl 3):16-24. doi: 10.20471/acc.2021.60.s3.02.
A prospective study was carried out at the Zagreb University Hospital Centre to evaluate the relationship between epilepsy, antiepileptic drugs (AEDs) and quality of life (QoL) in patients with epilepsy (PE), and its association with depressive symptoms and sexual dysfunction (SD). QoL was assessed by use of the Quality of Life in Epilepsy-31 Inventory (QOLIE-31), SD by the Arizona Sexual Experiences Scale (ASEX), and depressive symptoms by the Hamilton Rating Scale for Depression (HAM-D17). The study included 108 PE (women 63% and men 37% men), mean age 39.54±15.91 years. Focal type epilepsy was diagnosed in 14.8%, generalized type in 35.2%, and both types were present in 40.7% of study patients. Drug-resistant epilepsy (DRE) was present in 44/108 and vagus nerve stimulation (VNS) was implanted in 27/44 patients. The mean response on QOLIE-31 was 62.88±17.21 with no significant differences according to gender, type of epilepsy, and age. A statistically significantly lower QoL was found in the 'Overall QoL' domain (35-55 . <35 age group). Patients taking both types of AEDs had a significantly lower QoL compared to those on newer types of AEDs. Higher QoL was associated with less pronounced depressive symptoms (p=0.000). Significant correlations were found between lower QoL and SD (p=0.001). In 27 patients with DRE having undergone VNS, a favorable effect of VNS implantation on the QoL and mood was observed as compared with 18 patients without VNS (p=0.041).
一项前瞻性研究在萨格勒布大学医院中心进行，旨在评估癫痫患者（PE）中的癫痫、抗癫痫药物（AED）和生活质量（QoL）之间的关系，以及与抑郁症状和性功能障碍（SD）的关系。使用癫痫生活质量问卷 31 项（QOLIE-31）评估 QoL，使用亚利桑那性经验量表（ASEX）评估 SD，使用汉密尔顿抑郁量表 17 项（HAM-D17）评估抑郁症状。该研究纳入了 108 名 PE（女性占 63%，男性占 37%），平均年龄 39.54±15.91 岁。局灶性癫痫占 14.8%，全面性癫痫占 35.2%，两种类型均存在于 40.7%的研究患者中。耐药性癫痫（DRE）存在于 44/108 名患者中，27/44 名患者植入了迷走神经刺激器（VNS）。QOLIE-31 的平均反应为 62.88±17.21，性别、癫痫类型和年龄均无显著差异。在“总体 QoL”领域发现 QoL 显著较低（35-55 岁<35 岁年龄组）。服用两种类型 AED 的患者的 QoL 明显低于服用新型 AED 的患者。QoL 越高，抑郁症状越不明显（p=0.000）。QoL 与 SD 显著相关（p=0.001）。在接受 VNS 的 27 名 DRE 患者中，与未接受 VNS 的 18 名患者相比，VNS 植入对 QoL 和情绪产生了有利影响（p=0.041）。
