Sugawara T, Shingai J, Ogawa A, Wada T, Suzuki J, Namiki T
No Shinkei Geka. 1986 Jan;14(1):109-13.
A medulloblastoma in a 7-year-old girl showed complete remission after the initial radiotherapy of 5,000 rad. But she had three episodes of recurrence in the cerebellum and in the spinal cord, and was treated by additional radiotherapy for the lesions 3,000 to 5,000 rad. When the total cerebellar tumor dose became 13,300 rad, a fatal intratumoral hemorrhage occurred. Autopsy revealed a massive intratumoral hematoma and thin-walled tumor vessels which might be designated as "sinusoid" or "telangiectasia" microscopically. The authors proposed a possibility that the thin-walled vessels and the high dose of radiotherapy caused the hemorrhage.
一名7岁女孩的髓母细胞瘤在接受5000拉德的初始放疗后显示完全缓解。但她在小脑和脊髓出现了三次复发，并对这些病灶进行了3000至5000拉德的额外放疗。当小脑肿瘤的总剂量达到13300拉德时，发生了致命的肿瘤内出血。尸检显示有巨大的肿瘤内血肿和薄壁肿瘤血管，在显微镜下这些血管可能被认定为“血窦”或“毛细血管扩张”。作者提出一种可能性，即薄壁血管和高剂量放疗导致了出血。
