Breier A, Davis O R, Buchanan R W
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21201.
Psychopharmacology (Berl). 1991;104(4):479-84. doi: 10.1007/BF02245653.
The effects of benzodiazepine drugs and the role of their recognition site, the GABAA/benzodiazepine receptor, in acute glucoprivic stress are not known. In the present study, the effects of acute glucoprivation were examined in ten healthy human subjects. Glucoprivation was induced by infusion of the glucose analog, 2-deoxyglucose (2DG), at doses sufficient (50 mg/kg) to competitively inhibit glucose metabolism. In addition, the effects of the triazolobenzodiazepine alprazolam (1.5 mg) on the 2DG-induced stress response was assessed. 2DG produced significant elevations in plasma cortisol (P = 0.0001) and glucose (P = 0.0003) levels. Alprazolam pretreatment attenuated the 2DG-related cortisol elevations (P = 0.05) but did not effect 2DG-induced glucose increases. In addition, 2DG caused significant increases in hunger (P = 0.01) and thirst (P = 0.001), and alprazolam significantly blunted both of these responses. Lastly, 2DG had significant effects on heart rate, diastolic blood pressure and body temperature (P less than 0.05). Alprazolam did not effect these physiologic indices. The significance of these data for the mechanisms involved in acute glucoprivic stress are examined and the implications of the data for the pathophysiology of affective illness and eating disorders are discussed.
苯二氮䓬类药物的作用及其识别位点即GABAA/苯二氮䓬受体在急性低血糖应激中的作用尚不清楚。在本研究中，对10名健康人类受试者进行了急性低血糖影响的检测。通过输注葡萄糖类似物2-脱氧葡萄糖（2DG）来诱导低血糖，输注剂量足以（50mg/kg）竞争性抑制葡萄糖代谢。此外，评估了三唑苯二氮䓬阿普唑仑（1.5mg）对2DG诱导的应激反应的影响。2DG使血浆皮质醇（P = 0.0001）和葡萄糖（P = 0.0003）水平显著升高。阿普唑仑预处理减弱了与2DG相关的皮质醇升高（P = 0.05），但对2DG诱导的葡萄糖升高没有影响。此外，2DG导致饥饿感（P = 0.01）和口渴感（P = 0.001）显著增加，阿普唑仑显著减弱了这两种反应。最后，2DG对心率、舒张压和体温有显著影响（P小于0.05）。阿普唑仑对这些生理指标没有影响。本文研究了这些数据对于急性低血糖应激相关机制的意义，并讨论了这些数据对情感性疾病和饮食失调病理生理学的影响。
