Guyotat D, Mauduit G, Chouvet B, Kanitakis J, Van H V, Fiere D, Thivolet J
Transplantation. 1986 Mar;41(3):340-2. doi: 10.1097/00007890-198603000-00011.
Histological and immunopathological studies were performed on serial skin biopsies from thirteen recipients of allogenic and two recipients of autologous bone marrow transplants. Marked dermoepidermal infiltration with Leu 2a+ (OKT8+) phenotype cells was found in two patients with severe graft-versus-host disease, but the infiltration did not precede clinical onset of the graft-versus-host disease. Absence of Langerhans cells was noted during the early posttransplant period in recipients of both allogenic and autologous transplantation. Intercellular epidermal staining with anti-DR was observed in three cases, without relation to graft-versus-host disease.
对13例同种异体骨髓移植受者和2例自体骨髓移植受者的系列皮肤活检标本进行了组织学和免疫病理学研究。在2例患有严重移植物抗宿主病的患者中发现真皮表皮有明显的Leu 2a+（OKT8+）表型细胞浸润，但这种浸润并未先于移植物抗宿主病的临床发作。在同种异体和自体移植受者移植后的早期均观察到朗格汉斯细胞缺失。在3例中观察到抗DR细胞间表皮染色，与移植物抗宿主病无关。
