Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of L.

The antiproliferative activities of 2',3,4',5,5'-pentahydroxy--stilbene , resveratrol , oxyresveratrol , norartocarpetin , kuwanon C , morusin , cudraflavone A, kuwanon G , albafuran C , mulberrofuran G , 3-acetyl-α-amyrin , 3-acetyl--β-amyrin ursolic acid-3--acetate and uvaol , previously identified from the barks of L., were investigated against HepG2 and MCF-7 cell lines. In addition, a series of methylated stilbenes were prepared using compounds - and their antiproliferative effects were similarly investigated. The structure of a new 2',3,4'-trimethoxy-5-hydroxy--stilbene was elucidated using spectroscopic techniques. It showed remarkable activity against MCF-7 cells with IC 12.5 μM. However, kuwanon C () showed the highest antiproliferative activity with IC 3.92 and 9.54 μM against MCF-7 and HepG2, respectively.