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[来自桑树(Morus alba L.)叶子的黄酮类化合物]

[Flavonoids from the leaves of Morus alba L].

作者信息

Yang Yan, Wang Hong-Qing, Chen Ruo-Yun

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

出版信息

Yao Xue Xue Bao. 2010 Jan;45(1):77-81.

Abstract

The investigation on the leaves of Morus alba L. was carried out to find the relationship of the constituents and the pharmacological activities. The isolation and purification were performed by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography and so on. Further detailed investigation on the fraction of the ethanol extract of leaves of Morus alba yielded four Diels-Alder type adducts mulberrofuran F1 (1), mulberrofuran F (2), chalcomoracin (3), kuwanon J (4), together with two chalcones morachalcone A (5), isobavachalcone (6), and three flavones norartocarpetin (7), kuwanon C (8), 6-geranylapigenin (9). Their structures were elucidated by the spectral analysis such as NMR, MS etc. Compounds 1, 6 were isolated from this plant for the first time, compounds 4-5, 7-9 were isolated from the leaves of Morus alba L. for the first time, among which 1 was a new compound. Compounds 1-5 were evaluated for the cytotoxicity against A549, Be17402, BGC823, HCT-8 and A2780 cell lines in vitro by MTT method, but only compounds 1-3 showed cytotoxicity against several human cancer cell lines.

摘要

为了探寻构效关系,对桑叶展开了研究。通过硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱、反相C18柱色谱等多种色谱法进行分离纯化。对桑叶乙醇提取物的馏分进一步深入研究,得到了4种狄尔斯-阿尔德型加合物桑呋喃F1(1)、桑呋喃F(2)、查耳酮莫拉查耳酮A(5)、异补骨脂查耳酮(6)、3种黄酮去甲波罗蜜黄素(7)、桑酮C(8)、6 - 香叶基芹菜素(9)。通过核磁共振、质谱等光谱分析对它们的结构进行了确证。化合物1、6为首次从该植物中分离得到,化合物4 - 5、7 - 9为首次从桑叶中分离得到,其中化合物1为新化合物。采用MTT法对化合物1 - 5进行体外抗A549、Be17402、BGC823、HCT - 8和A2780细胞系的细胞毒性评价,结果显示只有化合物1 - 3对几种人类癌细胞系具有细胞毒性。

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