Donmez H H, Donmez N, Kısadere I, Undag I
a Department of Histology and Embryology, Faculty of Veterinary, University of Selcuk , Konya , Turkey.
b Department of Physiology, Faculty of Veterinary, University of Selcuk , Konya , Turkey.
Biotech Histochem. 2019 Jul;94(5):381-386. doi: 10.1080/10520295.2019.1574027. Epub 2019 Mar 1.
We investigated the effects of quercetin (Q) on some hematological parameters and determined the percentage of alpha-naphthyl acetate esterase (ANAE) positive lymphocytes in rats that had been exposed to cadmium (Cd). Thirty male Wistar albino rats were divided into four groups: control (C), quercetin (Q), cadmium (Cd) and Q + Cd (CdQ). Blood samples were taken to assess erythrocytes (RBC), leukocytes (WBC), hemoglobin levels (Hb), hematocrit values (Hct), platelets (PLT), alpha-naphthyl acetate esterase (ANAE) positive lymphocytes. RBC, Hb, Hct; the number of PLT significantly decreased in the Cd group. To the contrary, these parameters were increased significantly in the CdQ group compared to the Cd group. Although we found a significant increase in total WBC count and neutrophil percentage, the number of lymphocytes decreased in the Cd group compared to the other three groups. Also, the percentage of peripheral blood ANAE positive lymphocytes decreased significantly in the Cd group ( < 0.05). Q exhibits positive effects on some hematological characteristics and the percentage of ANAE positive lymphocyte in cases of acute CD toxicity.
我们研究了槲皮素（Q）对一些血液学参数的影响，并确定了暴露于镉（Cd）的大鼠中α-萘乙酸酯酶（ANAE）阳性淋巴细胞的百分比。将30只雄性Wistar白化大鼠分为四组：对照组（C）、槲皮素组（Q）、镉组（Cd）和Q + Cd组（CdQ）。采集血样以评估红细胞（RBC）、白细胞（WBC）、血红蛋白水平（Hb）、血细胞比容值（Hct）、血小板（PLT）、α-萘乙酸酯酶（ANAE）阳性淋巴细胞。Cd组的RBC、Hb、Hct和PLT数量显著降低。相反，与Cd组相比，CdQ组的这些参数显著增加。尽管我们发现Cd组的白细胞总数和中性粒细胞百分比显著增加，但与其他三组相比，Cd组的淋巴细胞数量减少。此外，Cd组外周血ANAE阳性淋巴细胞百分比显著降低（<0.05）。在急性镉中毒情况下，槲皮素对一些血液学特征和ANAE阳性淋巴细胞百分比具有积极影响。
