静脉注射死菌后兔类风湿因子和关节病变的实验性诱导
Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria.
作者信息
Hanglow A C, Welsh C J, Conn P, Pitts J M, Rampling A, Coombs R R
出版信息
Ann Rheum Dis. 1986 Jan;45(1):50-9. doi: 10.1136/ard.45.1.50.
Rabbits receiving repeated intravenous injections of killed bacteria (Escherichia coli or Bacillus subtilis) developed IgM rheumatoid factor which reacted with autologous heat-aggregated IgG. In addition, 5/7 'Old English' and 7/8 'Sandy Lop' rabbits receiving killed E. coli developed rheumatoid-like synovial lesions. 'Old English' rabbits developed lesions of a more severe nature. Three of eight 'Sandy Lop' rabbits injected with killed B. subtilis had high levels of rheumatoid factor but only mild joint lesions.
接受重复静脉注射灭活细菌（大肠杆菌或枯草芽孢杆菌）的兔子产生了与自体热聚集IgG反应的IgM类风湿因子。此外，接受灭活大肠杆菌注射的7只“古英国兔”中有5只、8只“沙地垂耳兔”中有7只出现了类风湿样滑膜病变。“古英国兔”出现的病变更为严重。8只注射了灭活枯草芽孢杆菌的“沙地垂耳兔”中有3只类风湿因子水平较高，但仅有轻微的关节病变。
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