血清甲苯达唑浓度与氨基比林呼气试验之间的相关性。对包虫病治疗的启示。
A correlation between serum mebendazole concentrations and the aminopyrine breath test. Implications in the treatment of hydatid disease.
作者信息
Bekhti A, Pirotte J, Woestenborghs R
出版信息
Br J Clin Pharmacol. 1986 Feb;21(2):223-6. doi: 10.1111/j.1365-2125.1986.tb05179.x.
Abstract
In 25 patients an [14C]-aminopyrine breath test (ABT) was performed immediately before the oral administration of 1.5-2 g of mebendazole three times daily. The concentration of mebendazole in serum was measured 2 h after each drug intake. A significant correlation was found between the results of ABT and the serum drug concentrations obtained after the second and third intake, as well as the highest concentration value. The ABT was repeated in six patients during a continuous treatment with mebendazole. In all of them this test indicated an increase in 14CO2 production with continued treatment. The results support the view that mebendazole is metabolized by the liver monooxygenase activity and behaves as an enzyme inducer.
摘要
在25名患者中，在每天口服3次1.5 - 2克甲苯咪唑之前立即进行[14C] - 氨基比林呼气试验（ABT）。每次服药后2小时测量血清中甲苯咪唑的浓度。发现ABT结果与第二次和第三次服药后获得的血清药物浓度以及最高浓度值之间存在显著相关性。在6名接受甲苯咪唑持续治疗的患者中重复进行了ABT。在所有这些患者中，该试验表明随着持续治疗，14CO2生成增加。结果支持甲苯咪唑由肝脏单加氧酶活性代谢并表现为酶诱导剂的观点。
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