Maske R, Hill J C, Oliver S P
Br J Ophthalmol. 1986 Mar;70(3):199-201. doi: 10.1136/bjo.70.3.199.
A prospective microbiological study of 48 patients with corneal ulcers due to bacterial infection was performed. Positive cultures of corneal ulcer samples were obtained in 60% of all patients; about half of these patients had received antimicrobial treatment prior to sampling. A relatively high incidence of Staphylococcus epidermidis was isolated from ulcer patients (27%) compared with normal controls (10%). Gram stains of ulcer samples were positive for organisms in only 27% of all patients and were not considered useful in determining initial therapy in this series. We concluded that treatment should be started with a broad combination of antibiotics while awaiting the culture results.
对48例因细菌感染导致角膜溃疡的患者进行了一项前瞻性微生物学研究。所有患者中60%的角膜溃疡样本培养呈阳性；这些患者中约一半在取样前接受过抗菌治疗。与正常对照组（10%）相比，从溃疡患者中分离出表皮葡萄球菌的发生率相对较高（27%）。在所有患者中，仅27%的溃疡样本革兰氏染色显示有微生物，在本系列研究中，革兰氏染色对确定初始治疗并无帮助。我们得出结论，在等待培养结果期间，应开始使用多种抗生素联合治疗。
