Faculty of Agriculture and Food Sciences, Universiti Putra Malaysia-Kampus Bintulu, Bintulu, Malaysia.
Infection Biology, University of Liverpool Institute of Infection and Global Health, Liverpool, UK.
Vet Rec. 2019 Apr 20;184(16):502. doi: 10.1136/vr.105209. Epub 2019 Mar 1.
The liver fluke is a parasitic trematode that has a major impact on livestock production and human health. Control of is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms.
肝片形吸虫是一种寄生的吸虫，对畜牧业生产和人类健康有重大影响。的控制很困难，依赖于驱虫药，特别是三氯苯达唑，因为它对寄生虫的成虫和幼虫阶段都有效。包括英国在内的许多国家都报告了三氯苯达唑耐药种群的出现，但三氯苯达唑耐药的总体流行率和分布情况尚不清楚。在这项研究中，作者使用经过验证的复合粪便卵计数减少试验，证实了英格兰和威尔士绵羊群中三氯苯达唑疗效降低的存在。2013 年秋季至 2015 年春季期间，从威尔士、英格兰西南部、西北部和东北部抽取了 74 个绵羊场的样本。在 42/74 个农场的样本中检测到了卵。在完成粪便卵计数减少试验的 26 个农场中的 21 个农场中，发现了三氯苯达唑疗效不佳的证据，粪便卵计数减少率从 89%到 0%不等。回归分析表明，和三氯苯达唑疗效不佳的流行率都存在空间相关性，英格兰西北部和威尔士的农场中，卵的流行率较高，而粪便卵计数减少率和百分比降低率较低。总的来说，结果表明，英格兰和威尔士都存在三氯苯达唑疗效降低的情况，在 26 个农场中有 9 个观察到完全缺乏治疗效果。
