Romagnani S, Maggi E, Biagiotti R, Giudizi M G, Amadori A, Ricci M
Scand J Immunol. 1978;7(6):511-4. doi: 10.1111/j.1365-3083.1978.tb00485.x.
The ability of peripheral blood lymphocytes from patients with Hodgkin's disease (HD) to form rosettes with ox red blood cells (ORBC) sensitized by anti-ORBC purified rabbit IgM and IgG was investigated. The mean percentage of cells capable of forming rosettes with ORBC coated with IgM (EAIgM-RFC) in the peripheral blood of either untreated or X-ray-treated patients with HD was significantly lower than that of normal individuals. In the same groups of patients with HD the mean percentage of T lymphocytes equipped with receptor for IgG (T gamma lymphocytes), evaluated by a mixed fluorescent rosette assay, was significantly higher than in normal controls. These data suggest that the altered proportion between T mu-and T gamma-cell subpopulations in patients with HD probably represents a disease-related phenomenon.
研究了霍奇金病（HD）患者外周血淋巴细胞与经抗牛红细胞（ORBC）纯化兔IgM和IgG致敏的牛红细胞（ORBC）形成玫瑰花结的能力。未经治疗或经X射线治疗的HD患者外周血中能够与IgM包被的ORBC形成玫瑰花结的细胞（EAIgM-RFC）的平均百分比显著低于正常个体。在同一组HD患者中，通过混合荧光玫瑰花结试验评估的配备IgG受体的T淋巴细胞（Tγ淋巴细胞）的平均百分比显著高于正常对照。这些数据表明，HD患者Tμ细胞和Tγ细胞亚群之间比例的改变可能代表一种与疾病相关的现象。
