Department of Radiotherapy, University Medical Center Utrecht, the Netherlands.
Department of Radiotherapy, University Medical Center Utrecht, the Netherlands.
Radiother Oncol. 2019 Mar;132:114-120. doi: 10.1016/j.radonc.2018.12.011. Epub 2018 Dec 31.
Magnetic Resonance linear accelerator (MR-linac) systems represent a new type of technology that allows for online MR-guidance for high precision radiotherapy (RT). Currently, the first MR-linac installations are being introduced clinically. Since the imaging performance of these integrated MR-linac systems is critical for their application, a thorough commissioning of the MRI performance is essential. However, guidelines on the commissioning of MR-guided RT systems are not yet defined and data on the performance of MR-linacs are not yet available.
MATERIALS & METHODS: Here we describe a comprehensive commissioning protocol, which contains standard MRI performance measurements as well as dedicated hybrid tests that specifically assess the interactions between the Linac and the MRI system. The commissioning results of four MR-linac systems are presented in a multi-center study.
Although the four systems showed similar performance in all the standard MRI performance tests, some differences were observed relating to the hybrid character of the systems. Field homogeneity measurements identified differences in the gantry shim configuration, which was later confirmed by the vendor.
Our results highlight the importance of dedicated hybrid commissioning tests and the ability to compare the machines between institutes at this very early stage of clinical introduction. Until formal guidelines and tolerances are defined the tests described in this study may be used as a practical guideline. Moreover, the multi-center results provide initial bench mark data for future MR-linac installations.
磁共振直线加速器(MR-linac)系统代表了一种新技术,可实现高精度放疗(RT)的在线磁共振引导。目前,正在临床引入第一批 MR-linac 设备。由于这些集成的 MR-linac 系统的成像性能对其应用至关重要,因此必须对 MRI 性能进行彻底的调试。然而,目前还没有关于 MR 引导 RT 系统调试的指南,也没有关于 MR-linac 性能的数据。
在这里,我们描述了一个全面的调试协议,其中包含标准的 MRI 性能测量以及专门的混合测试,这些测试专门评估直线加速器和 MRI 系统之间的相互作用。在一项多中心研究中介绍了四个 MR-linac 系统的调试结果。
尽管这四个系统在所有标准 MRI 性能测试中均表现出相似的性能,但在与系统混合特性相关的某些方面观察到了差异。场均匀性测量确定了龙门架调谐器配置的差异,后来供应商对此进行了确认。
我们的结果强调了专用混合调试测试的重要性,以及在临床引入的早期阶段在机构之间比较机器的能力。在正式指南和公差定义之前,本研究中描述的测试可以用作实用指南。此外,多中心结果为未来的 MR-linac 安装提供了初步的基准数据。