局限期小细胞肺癌（SCLC）每日分割放疗的最佳时机：简要报告。
Optimal timing of thoracic radiotherapy in limited stage small cell lung cancer (SCLC) with daily fractionation: A brief report.
机构信息
Allegheny Health Network Cancer Institute, Division of Radiation Oncology, Pittsburgh.
Allegheny Health Network, Department of Internal Medicine, Pittsburgh.
出版信息
Radiother Oncol. 2019 Mar;132:23-26. doi: 10.1016/j.radonc.2018.11.005. Epub 2018 Dec 20.
Abstract
Survival in limited stage small cell lung cancer (LS-SCLC) improves with faster initiation of hyper-fractionated thoracic radiotherapy (TRT) following chemotherapy, however, it is unknown if this association exists for more commonly employed daily fractionated regimens. Our results suggest that this association is present even with daily fractionation.
摘要
局限期小细胞肺癌（LS-SCLC）患者的生存率随着化疗后更快开始超分割胸部放射治疗（TRT）而提高，但是否与更常用的每日分割方案存在这种关联尚不清楚。我们的结果表明，即使采用每日分割，这种关联也存在。
相似文献
1
Optimal timing of thoracic radiotherapy in limited stage small cell lung cancer (SCLC) with daily fractionation: A brief report.局限期小细胞肺癌（SCLC）每日分割放疗的最佳时机：简要报告。
Radiother Oncol. 2019 Mar;132:23-26. doi: 10.1016/j.radonc.2018.11.005. Epub 2018 Dec 20.
2
Patient-reported health-related quality of life from a randomized phase II trial comparing standard-dose with high-dose twice daily thoracic radiotherapy in limited stage small-cell lung cancer.一项随机II期试验中患者报告的与健康相关的生活质量，该试验比较了标准剂量与高剂量每日两次胸部放疗在局限期小细胞肺癌中的应用。
Lung Cancer. 2022 Apr;166:49-57. doi: 10.1016/j.lungcan.2022.02.002. Epub 2022 Feb 8.
3
Effects of thoracic radiotherapy timing and duration on progression-free survival in limited-stage small cell lung cancer.胸部放疗时机和时间对局限期小细胞肺癌无进展生存期的影响。
Cancer Med. 2018 Sep;7(9):4208-4216. doi: 10.1002/cam4.1616. Epub 2018 Jul 17.
4
Radiation Dose and Fractionation for Limited-stage Small-cell Lung Cancer: Survey of US Radiation Oncologists on Practice Patterns.局限期小细胞肺癌的放射剂量和分割：对美国放射肿瘤学家实践模式的调查。
Clin Lung Cancer. 2019 Jan;20(1):13-19. doi: 10.1016/j.cllc.2018.08.015. Epub 2018 Aug 22.
5
Twice-daily Thoracic Radiotherapy for Limited-stage Small-cell Lung Cancer Does Not Increase the Incidence of Acute Severe Esophagitis.每日两次胸部放疗用于局限期小细胞肺癌并不会增加急性重度食管炎的发生率。
Clin Lung Cancer. 2018 Nov;19(6):e885-e891. doi: 10.1016/j.cllc.2018.08.012. Epub 2018 Aug 22.
6
Timing of thoracic radiotherapy is more important than dose intensification in patients with limited-stage small cell lung cancer: a parallel comparison of two prospective studies.局限期小细胞肺癌患者的胸部放疗时间比剂量强化更重要：两项前瞻性研究的平行比较。
Strahlenther Onkol. 2020 Feb;196(2):172-181. doi: 10.1007/s00066-019-01539-1. Epub 2019 Nov 29.
7
Receipt of thoracic radiation therapy and radiotherapy dose are correlated with outcomes in a retrospective study of three hundred and six patients with extensive stage small-cell lung cancer.在一项针对306例广泛期小细胞肺癌患者的回顾性研究中，接受胸部放射治疗及放疗剂量与预后相关。
Radiother Oncol. 2017 Nov;125(2):331-337. doi: 10.1016/j.radonc.2017.10.005. Epub 2017 Oct 24.
8
Consolidative thoracic radiotherapy in stage IV small cell lung cancer: Selection of patients amongst European IASLC and ESTRO experts.局限期小细胞肺癌的胸部巩固性放疗：欧洲国际肺癌研究协会和欧洲放射肿瘤学会专家对患者的选择。
Radiother Oncol. 2019 Jun;135:74-77. doi: 10.1016/j.radonc.2019.02.010. Epub 2019 Mar 15.
9
Thoracic Radiation in Limited Stage Small Cell Lung Cancer: Trends in Radiation Fractionation.局限期小细胞肺癌的胸部放疗：放疗分割方式的趋势。
Clin Lung Cancer. 2023 Jun;24(4):322-328. doi: 10.1016/j.cllc.2023.02.001. Epub 2023 Feb 7.
10
Guideline for the Initial Management of Small Cell Lung Cancer (Limited and Extensive Stage) and the Role of Thoracic Radiotherapy and First-line Chemotherapy.小细胞肺癌（局限期和广泛期）初始治疗指南及胸部放疗和一线化疗的作用。
Clin Oncol (R Coll Radiol). 2018 Oct;30(10):658-666. doi: 10.1016/j.clon.2018.06.008. Epub 2018 Jul 11.
引用本文的文献
1
Sequential Hypofractionated versus Concurrent Twice-Daily Radiotherapy for Limited-Stage Small-Cell Lung Cancer: A Propensity Score-Matched Analysis.序贯低分割放疗与同步每日两次放疗治疗局限期小细胞肺癌的倾向评分匹配分析
Cancers (Basel). 2022 Aug 13;14(16):3920. doi: 10.3390/cancers14163920.
2
Optimal timing of thoracic irradiation for limited stage small cell lung cancer: Current evidence and future prospects.局限期小细胞肺癌胸段放疗的最佳时机：当前证据与未来展望
World J Clin Oncol. 2022 Feb 24;13(2):116-124. doi: 10.5306/wjco.v13.i2.116.
3
One Cycle of Concurrent Chemotherapy vs. Two Cycles of Concurrent Chemotherapy With Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer.局限期小细胞肺癌患者同步化疗一个周期与同步化疗两个周期联合放射治疗的比较。
Front Oncol. 2022 Jan 24;11:785022. doi: 10.3389/fonc.2021.785022. eCollection 2021.
4
Pre-radiotherapy lymphocyte count and platelet-to-lymphocyte ratio may improve survival prediction beyond clinical factors in limited stage small cell lung cancer: model development and validation.放疗前淋巴细胞计数和血小板与淋巴细胞比值可能改善局限期小细胞肺癌临床因素之外的生存预测：模型构建与验证
Transl Lung Cancer Res. 2020 Dec;9(6):2315-2327. doi: 10.21037/tlcr-20-666.
5
Optimal timing of radiotherapy in high risk prostate cancer: Do missed days matter?高危前列腺癌放疗的最佳时机：错过的天数重要吗？
Clin Transl Radiat Oncol. 2020 Nov 25;26:47-54. doi: 10.1016/j.ctro.2020.11.006. eCollection 2021 Jan.
6
Future Options of Molecular-Targeted Therapy in Small Cell Lung Cancer.小细胞肺癌分子靶向治疗的未来选择
Cancers (Basel). 2019 May 17;11(5):690. doi: 10.3390/cancers11050690.
本文引用的文献
1
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.局限期小细胞肺癌患者同步每日一次与每日两次放化疗的比较（CONVERT）：一项开放标签、3期、随机、优效性试验
Lancet Oncol. 2017 Aug;18(8):1116-1125. doi: 10.1016/S1470-2045(17)30318-2. Epub 2017 Jun 20.
2
Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis.胸部放疗时机对局限期小细胞肺癌的影响：个体患者数据荟萃分析的效用
Ann Oncol. 2016 Oct;27(10):1818-28. doi: 10.1093/annonc/mdw263. Epub 2016 Jul 19.
3
Utilization of Hyperfractionated Radiation in Small-Cell Lung Cancer and Its Impact on Survival.超分割放射治疗在小细胞肺癌中的应用及其对生存的影响。
J Thorac Oncol. 2015 Dec;10(12):1770-5. doi: 10.1097/JTO.0000000000000672.
4
An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.倾向得分法在观察性研究中减少混杂效应的介绍
Multivariate Behav Res. 2011 May;46(3):399-424. doi: 10.1080/00273171.2011.568786. Epub 2011 Jun 8.
5
Timing of chest radiotherapy in patients with limited stage small cell lung cancer: a systematic review and meta-analysis of randomised controlled trials.局限期小细胞肺癌患者胸部放疗的时机：随机对照试验的系统评价和荟萃分析
Cancer Treat Rev. 2007 Aug;33(5):461-73. doi: 10.1016/j.ctrv.2007.03.002. Epub 2007 May 21.
6
Time between the first day of chemotherapy and the last day of chest radiation is the most important predictor of survival in limited-disease small-cell lung cancer.化疗第一天至胸部放疗最后一天之间的时间是局限期小细胞肺癌生存的最重要预测因素。
J Clin Oncol. 2006 Mar 1;24(7):1057-63. doi: 10.1200/JCO.2005.02.9793.
7
Systematic review and meta-analysis of randomised, controlled trials of the timing of chest radiotherapy in patients with limited-stage, small-cell lung cancer.局限期小细胞肺癌患者胸部放疗时机的随机对照试验的系统评价和荟萃分析
Ann Oncol. 2006 Apr;17(4):543-52. doi: 10.1093/annonc/mdj094. Epub 2005 Dec 12.
8
Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.倾向得分法在治疗组与非随机对照组比较中减少偏倚的应用
Stat Med. 1998 Oct 15;17(19):2265-81. doi: 10.1002/(sici)1097-0258(19981015)17:19<2265::aid-sim918>3.0.co;2-b.
Zotero 插件