饮酒导致男性血小板抑制。

Consumption of alcohol leads to platelet inhibition in men.

机构信息

Oregon Health & Science University, USA.

出版信息

Am J Surg. 2019 May;217(5):868-872. doi: 10.1016/j.amjsurg.2019.02.020. Epub 2019 Feb 23.

DOI:10.1016/j.amjsurg.2019.02.020

PMID:30826005

Abstract

INTRODUCTION

Alcohol consumption has been shown to alter coagulation. However, thromboelastography with platelet mapping (TEG PM) to evaluate platelet function has not been studied.

METHODS

A prospective, non-randomized study of healthy volunteers was conducted. Baseline TEG PM were collected. Subjects consumed alcoholic or non-alcoholic beverages for 2 h. Repeat TEG PM was collected.

RESULTS

Fifty-four volunteers entered either the experimental group (EG, 17 women and 16 men) or control group (CG, 11 women and 10 men). After 2 h of alcohol or non-alcoholic drink consumption the median breath alcohol level was 0.08 [IQR 0.05, 0.12] in the EG and 0.00 in the CG. After consumption of alcohol, male EG subjects demonstrated higher median Adenosine Diphosphate (ADP) inhibition of platelet function (15.7% [3.9, 39.3] vs 8.2% [0, 30.1), p = 0.035), but female subjects did not. There was no evidence of increased arachidonic acid (AA) platelet inhibition in the EG compared to CG. Clot strength (TEG maximum amplitude) was not different between groups.

CONCLUSION

After consumption of alcohol, healthy male volunteers demonstrate ADP platelet inhibition by TEG PM.

摘要

简介

已有研究表明，饮酒会改变凝血功能。然而，尚未有研究使用血栓弹力图血小板图（TEG PM）评估血小板功能。

方法

对健康志愿者进行前瞻性、非随机研究。采集基线 TEG PM。志愿者饮用酒精或非酒精饮料 2 小时。重复采集 TEG PM。

结果

54 名志愿者分别进入实验组（EG，17 名女性和 16 名男性）或对照组（CG，11 名女性和 10 名男性）。在饮用酒精或非酒精饮料 2 小时后，EG 组的中位呼气酒精水平为 0.08[IQR 0.05，0.12]，CG 组为 0.00。在摄入酒精后，男性 EG 组的 ADP 抑制血小板功能的中位值更高（15.7%[3.9，39.3]比 8.2%[0，30.1]，p=0.035），但女性组没有。与 CG 相比，EG 组中未发现 AA 血小板抑制增加。各组间的血凝块强度（TEG 最大振幅）无差异。