Department of Emergency Medicine, Health of Sciences Umraniye Training and Research Hospital, Istanbul, Turkey.
Department of Emergency Medicine, Bahcesehir University, Istanbul, Turkey.
Am J Emerg Med. 2019 Nov;37(11):2051-2054. doi: 10.1016/j.ajem.2019.02.037. Epub 2019 Feb 25.
Lack of a rapid biochemical test for acute stroke is a limitation in the diagnosis and management of acute stroke. The aim of this study is to evaluate the efficacy of BDNF and VILIP-1 as diagnostic markers in acute ischemic stroke and as predictors of mortality.
The study included 75 patients with acute ischemic stroke older than 18 years. During the same period, 28 normal controls were recruited from the hospital ED. Blood samples were collected from all patients at admission to determine the levels of VILIP-1 and BDNF.
The mean VILIP-1 levels in the study and control groups were 0.547 ± 0.081 and 0.515 ± 0.035 ng/mL, respectively, and the difference was not significant (p = 0.071). The mean BDNF levels in the study and control groups were 3.89 ± 2.05 ng/mL and 14.9 ± 4.7 ng/mL, respectively, and the level was significantly (p < 0.0001) lower in the stroke patients.
The BDNF level showed a significant ability to discriminate stroke and control patients but did not predict mortality. The VILIP-1 level showed insignificant ability to discriminate stroke patients and again did not predict mortality.
缺乏用于急性脑卒中的快速生化检测是急性脑卒中诊断和治疗中的一个限制。本研究旨在评估 BDNF 和 VILIP-1 作为急性缺血性脑卒中诊断标志物的疗效，以及作为死亡率预测因子的作用。
本研究纳入了 75 名年龄大于 18 岁的急性缺血性脑卒中患者。同期，从医院急诊部招募了 28 名正常对照者。所有患者入院时均采集血样以测定 VILIP-1 和 BDNF 水平。
研究组和对照组的平均 VILIP-1 水平分别为 0.547±0.081 和 0.515±0.035ng/mL，差异无统计学意义（p=0.071）。研究组和对照组的平均 BDNF 水平分别为 3.89±2.05ng/mL 和 14.9±4.7ng/mL，脑卒中患者的 BDNF 水平显著降低（p<0.0001）。
BDNF 水平能够显著区分脑卒中患者和对照组，但不能预测死亡率。VILIP-1 水平区分脑卒中患者的能力不显著，同样不能预测死亡率。
