Masaki Hitoshi, Doi Moeko
School of Bioscience and Biotechnology, Tokyo University of Technology.
DAITO KASEI KOGYO CO., LTD.
Yakugaku Zasshi. 2019;139(3):371-379. doi: 10.1248/yakushi.18-00177-3.
Sacran, a large molecular-weight polysaccharide isolated from algae, is composed of 11 types of saccharides, including sulfate and carboxylic acid groups. Because of its unique structure, sacran can form a gel-like sheet in the presence of polyols such as 1,3-butanediol. In addition, those sacran gel-like sheets prevent the evaporation of water and the penetration of chemicals. The results of our previous study suggested that sacran can work as an artificial barrier against external stimuli such as air pollutants which increase the stress on humans. Topically applied sacran was localized at the surface of reconstructed human epidermal equivalents. Those results suggested that sacran inhibits excessive water evaporation from the skin and protects against environmental stimuli by forming an artificial barrier at the skin surface. Then, in a clinical study, we examined the activity of sacran in improving skin problems caused by an impaired epidermal barrier. First, we conducted a use test on a serum formulated with sacran on human volunteers who had impaired skin barrier function. The results showed that sacran provided excellent benefits to improve the maturation of corneocytes. These results suggest that sacran could play an important role in providing optimal skin conditions for keratinocytes to progress through their differentiation.
Sacran是一种从藻类中分离出的大分子多糖，由11种糖类组成，包括硫酸根和羧酸基团。由于其独特的结构，Sacran在诸如1,3 - 丁二醇等多元醇存在的情况下能够形成凝胶状薄片。此外，这些Sacran凝胶状薄片可防止水分蒸发和化学物质渗透。我们之前的研究结果表明，Sacran可以作为一种人工屏障，抵御诸如增加人类压力的空气污染物等外部刺激。局部应用的Sacran定位于重建的人表皮等效物表面。这些结果表明，Sacran通过在皮肤表面形成人工屏障来抑制皮肤过度水分蒸发并抵御环境刺激。然后，在一项临床研究中，我们研究了Sacran在改善由表皮屏障受损引起的皮肤问题方面的活性。首先，我们对皮肤屏障功能受损的人类志愿者进行了一项使用含Sacran血清的测试。结果表明，Sacran在促进角质形成细胞成熟方面具有显著效果。这些结果表明，Sacran在为角质形成细胞的分化提供最佳皮肤条件方面可能发挥重要作用。
