Lentferink Yvette E, Kromwijk Lisa A J, van der Aa Marloes P, Knibbe Catherijne A J, van der Vorst Marja M J
St. Antonius Hospital, Nieuwegein, Netherlands.
Glob Pediatr Health. 2019 Feb 25;6:2333794X19831297. doi: 10.1177/2333794X19831297. eCollection 2019.
Increased arterial stiffness (AS) is an early sign of cardiovascular disease. Influence of weight, puberty, and insulin resistance (IR) on AS in adolescents is unclear. Therefore, this study compared AS, assessed with pulse wave velocity (PWV) and augmentation index (AIx), of adolescents with and without obesity and evaluated the influence of puberty and IR on AS. Sixty-two lean and 61 adolescents with obesity were included. Significantly higher PWV was observed in adolescents with obesity (4.1 ms [2.4 to 5.6 ms] vs 3.6 ms [0.4 to 6.1 ms]; = .01), while AIx was not significant different. However, significantly higher AIx was observed in adolescents with obesity and IR (3.0 [-17.5% to 28.5%] vs -3.0 [-19.0% to 13.0%]; = .01). For Tanner stages, no differences were observed. The higher PWV in adolescents with obesity and higher AIx in adolescents with obesity and IR both indicate an increased AS. Consequently, measurement of AS should be considered in adolescents with obesity and IR as part of cardiovascular risk assessment.
动脉僵硬度增加（AS）是心血管疾病的早期迹象。体重、青春期和胰岛素抵抗（IR）对青少年AS的影响尚不清楚。因此，本研究比较了通过脉搏波速度（PWV）和增强指数（AIx）评估的肥胖青少年和非肥胖青少年的AS，并评估了青春期和IR对AS的影响。纳入了62名瘦青少年和61名肥胖青少年。肥胖青少年的PWV显著更高（4.1米/秒[2.4至5.6米/秒]对3.6米/秒[0.4至6.1米/秒]；P = 0.01），而AIx无显著差异。然而，肥胖且有IR的青少年的AIx显著更高（3.0[-17.5%至28.5%]对-3.0[-19.0%至13.0%]；P = 0.01）。对于坦纳分期，未观察到差异。肥胖青少年中较高的PWV以及肥胖且有IR的青少年中较高的AIx均表明AS增加。因此，对于肥胖且有IR的青少年，应考虑将AS测量作为心血管风险评估的一部分。
