Negreira Alyson M, Abdallah Chadi G
Clinical Neurosciences Division, United States Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Chronic Stress (Thousand Oaks). 2019 Jan-Dec;3. doi: 10.1177/2470547019829035. Epub 2019 Feb 25.
Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder with a complex clinical presentation. The last two decades have seen a proliferation of literature on the neurobiological mechanisms subserving affective processing in PTSD. The current review will summarize the neuroimaging results of the most common experimental designs used to elucidate the affective signature of PTSD. From this summary, we will provide a heuristic to organize the various paradigms discussed and report neural patterns of activations using this heuristic as a framework. Next, we will compare these results to the traditional functional neurocircuitry model of PTSD and discuss biological and analytic variables which may account for the heterogeneity within this literature. We hope that this approach may elucidate the role of experimental parameters in influencing neuroimaging findings.
创伤后应激障碍（PTSD）是一种临床表现复杂的慢性致残性精神障碍。在过去二十年中，关于PTSD情感加工背后神经生物学机制的文献大量涌现。本综述将总结用于阐明PTSD情感特征的最常见实验设计的神经影像学结果。基于这一总结，我们将提供一种启发式方法来组织所讨论的各种范式，并以该启发式方法为框架报告激活的神经模式。接下来，我们将把这些结果与PTSD的传统功能性神经回路模型进行比较，并讨论可能解释该文献中异质性的生物学和分析变量。我们希望这种方法能够阐明实验参数在影响神经影像学结果方面的作用。
