Lyerly D M, Wilkins T D
J Clin Microbiol. 1986 Mar;23(3):622-3. doi: 10.1128/jcm.23.3.622-623.1986.
The rapid latex test recently marketed by Marion Scientific (Div. Marion Laboratories, Inc., Kansas City, Mo.) for the detection of Clostridium difficile toxin A does not react with the toxin, based on the following findings: culture filtrates from nontoxigenic strains of C. difficile gave positive reactions in the test, culture filtrate in which toxin A had been removed gave positive reactions, purified toxin A did not react in the test, and the latex reagent bound an antigen which is distinct from toxin A and which is produced in various amounts by both toxigenic and nontoxigenic strains of C. difficile.
马里恩科学公司（马里恩实验室公司分部，密苏里州堪萨斯城）近期推出的用于检测艰难梭菌毒素A的快速乳胶试验，基于以下发现，该试验与毒素不发生反应：来自艰难梭菌非产毒菌株的培养滤液在该试验中呈阳性反应，去除毒素A后的培养滤液呈阳性反应，纯化的毒素A在该试验中不发生反应，并且乳胶试剂结合了一种与毒素A不同的抗原，该抗原由艰难梭菌的产毒菌株和非产毒菌株以不同量产生。
