Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South Korea; and.
Department of Ophthalmology, Konyang University College of Medicine, Daejeon, South Korea.
Retina. 2020 Jun;40(6):1124-1131. doi: 10.1097/IAE.0000000000002489.
To evaluate the incidence of multifocal lesions and the distribution of lesion location in Type 3 neovascularization.
This retrospective, observational study included 148 eyes of 148 patients diagnosed with Type 3 neovascularization. The number of Type 3 neovascularization lesions was counted, and the incidence of multiple lesions in an eye was estimated. In addition, the distance from the fovea to the lesion and the geographic location of the lesion were estimated. Pseudodrusen incidence was compared between eyes with and without multifocal lesions.
In total, 169 Type 3 neovascularization lesions were noted. A single lesion was noted in 130 eyes (87.8%), whereas 2 or 3 multifocal lesions were noted in the remaining 18 eyes (12.2%). The mean distance from the fovea to the lesion was 898.8 ± 324.9 µm. The distribution of lesion locations exhibited a fovea-sparing pattern. No lesions were located within 200 µm of the fovea, 20 lesions (11.8%) were located >200 and ≤500 µm away from the fovea, 89 lesions (52.7%) were located >500 and ≤1,000 µm away from the fovea, and 60 lesions (35.5%) were located >1,000 µm away from the fovea. Pseudodrusen incidence was significantly higher in eyes with multifocal lesions (P = 0.024).
Two or more multifocal lesions were noted in 12.2% of eyes with Type 3 neovascularization, and pseudodrusen incidence was higher in eyes with multifocal lesions. In addition, lesion distribution exhibited a fovea-sparing pattern. These characteristics may be associated with the distinct pathophysiology of Type 3 neovascularization.
评估 3 型新生血管中多发病变的发生率和病变位置分布。
本回顾性观察性研究纳入了 148 例（148 只眼）诊断为 3 型新生血管的患者。对 3 型新生血管病变的数量进行计数，并估计每只眼多发病变的发生率。此外，还估计了病变与黄斑中心凹的距离和病变的地理位置。比较了多发病变眼与无多发病变眼的假性小体发生率。
共发现 169 处 3 型新生血管病变。130 只眼（87.8%）仅存在 1 处病变，18 只眼（12.2%）存在 2 处或 3 处多发病变。病变与黄斑中心凹的平均距离为 898.8±324.9μm。病变位置分布呈黄斑中心凹保留模式。没有病变位于距黄斑中心凹 200μm 以内，20 处病变（11.8%）位于距黄斑中心凹 200μm 至 500μm 之间，89 处病变（52.7%）位于距黄斑中心凹 500μm 至 1000μm 之间，60 处病变（35.5%）位于距黄斑中心凹 1000μm 以外。多发病变眼的假性小体发生率明显更高（P=0.024）。
3 型新生血管中 12.2%的眼存在 2 处或更多多发病变，多发病变眼的假性小体发生率更高。此外，病变分布呈黄斑中心凹保留模式。这些特征可能与 3 型新生血管独特的病理生理学有关。
