新生儿脐血延迟处理后血浆脂质组学变化最小。
Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood.
机构信息
Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia.
出版信息
Metabolomics. 2018 Sep 25;14(10):130. doi: 10.1007/s11306-018-1434-9.
BACKGROUND
Cord blood lipids are potential disease biomarkers. We aimed to determine if their concentrations were affected by delayed blood processing.
METHOD
Refrigerated cord blood from six healthy newborns was centrifuged every 12 h for 4 days. Plasma lipids were analysed by liquid chromatography/mass spectroscopy.
RESULTS
Of 262 lipids identified, only eight varied significantly over time. These comprised three dihexosylceramides, two phosphatidylserines and two phosphatidylethanolamines whose relative concentrations increased and one sphingomyelin that decreased.
CONCLUSION
Delay in separation of plasma from refrigerated cord blood has minimal effect overall on the plasma lipidome.
背景
脐带血中的脂质可能是疾病的生物标志物。本研究旨在确定其浓度是否受到延迟采血处理的影响。
方法
对 6 名健康新生儿的冷藏脐带血每隔 12 小时离心 4 天。采用液相色谱/质谱法分析血浆脂质。
结果
在所鉴定的 262 种脂质中，仅有 8 种随时间显著变化。这包括三种二己糖神经酰胺、两种磷脂酰丝氨酸和两种磷脂酰乙醇胺，它们的相对浓度增加，一种鞘磷脂则减少。
结论
冷藏脐带血的血浆分离延迟对整体血浆脂质组的影响很小。
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