从高等植物中发现新型抗癌剂。
Discovery of new anticancer agents from higher plants.
作者信息
Pan Li, Chai Hee-Byung, Kinghorn Alan Douglas
机构信息
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Front Biosci (Schol Ed). 2012 Jan 1;4(1):142-56. doi: 10.2741/s257.
Abstract
Small organic molecules derived from higher plants have been one of the mainstays of cancer chemotherapy for approximately the past half a century. In the present review, selected single chemical entity natural products of plant origin and their semi-synthetic derivatives currently in clinical trials are featured as examples of new cancer chemotherapeutic drug candidates. Several more recently isolated compounds obtained from plants showing promising in vivo biological activity are also discussed in terms of their potential as anticancer agents, with many of these obtained from species that grow in tropical regions. Since extracts of only a relatively small proportion of the ca. 300,000 higher plants on earth have been screened biologically to date, bioactive compounds from plants should play an important role in future anticancer drug discovery efforts.
摘要
在过去大约半个世纪里，源自高等植物的小分子有机化合物一直是癌症化疗的主要支柱之一。在本综述中，选取了一些植物来源的单一化学实体天然产物及其目前正在进行临床试验的半合成衍生物，作为新型癌症化疗候选药物的实例。还讨论了几种最近从植物中分离出的化合物，这些化合物在体内显示出有前景的生物活性，并探讨了它们作为抗癌剂的潜力，其中许多化合物来自生长在热带地区的物种。由于迄今为止仅对地球上约30万种高等植物中相对较小比例的植物提取物进行了生物学筛选，植物来源的生物活性化合物在未来抗癌药物的发现工作中应发挥重要作用。
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