Pandey Saurabh, Shaw Paul N, Hewavitharana Amitha K
School of Pharmacy, The University of Queensland, Brisbane, Australia.
Anticancer Agents Med Chem. 2015;15(3):314-26. doi: 10.2174/1871520614666141114202104.
Tropical plants are important sources of anti-cancer lead molecules. According to the US National Cancer Institute, out of the 3000 plants identified as active against cancer using in vitro studies, 70% are of tropical origin. The extraction of bioactive compounds from the plant materials is a fundamental step whose efficiency is critical for the success of drug discovery efforts. There has been no review published of the extraction procedures of anti-cancer compounds from tropical plants and hence the following is a critical evaluation of such procedures undertaken prior to the use of these compounds in cancer cell line studies, during the last five years. It presents a comprehensive analysis of all approaches taken to extract anti-cancer compounds from various tropical plants. (Databases searched were PubMed, SciFinder, Web of Knowledge, Scopus, Embase and Google Scholar).
热带植物是抗癌先导分子的重要来源。根据美国国立癌症研究所的数据，在通过体外研究确定具有抗癌活性的3000种植物中，70% 原产于热带地区。从植物材料中提取生物活性化合物是一个基本步骤，其效率对于药物研发工作的成功至关重要。此前尚未有关于从热带植物中提取抗癌化合物程序的综述发表，因此，以下是对过去五年在癌细胞系研究中使用这些化合物之前所采用的此类程序的批判性评估。它对从各种热带植物中提取抗癌化合物所采用的所有方法进行了全面分析。（检索的数据库有PubMed、SciFinder、Web of Knowledge、Scopus、Embase和谷歌学术）
