School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China.
Ecotoxicol Environ Saf. 2019 Jun 15;174:218-223. doi: 10.1016/j.ecoenv.2019.02.085. Epub 2019 Mar 1.
To explore the acute health effects of ozone(O) and PM on daily cardiovascular disease mortality in all the cities of Jiangsu province, China. Daily average concentrations of ozone (maximum 8-h average), fine particle matter (PM), meteorological data (including temperature and relative humidity) and daily cardiovascular diseases mortality data were collected from January 1, 2015, to December 31, 2017, in all the 13 cities of Jiangsu Province in China. The time-series model linked with Poisson distribution was used to estimate the correlation between O and daily cardiovascular diseases mortality, after adjusting for PM and other pollutants. Firstly, we evaluated the acute effects of O on cardiovascular mortality in each city in Jiangsu province, and then we combined the effects of O on cardiovascular disease mortality by meta-analysis. The single-pollutant model indicated that the acute health effects of O in different cities were quite different. After combined the effects of 13 cities, the mortality of cardiovascular diseases increased by 0.983%（95%CI：0.588-1.377%）for every 10 μg/m increases of O. O showed the strongest effect on 3-day moving average concentration (Lag 0-3). After adjusting PMNO, SO, and CO, the results were still statistically significant at the multi-city level. The study found that O had a greater effect on women; the elderly population was susceptible and high-education groups were more vulnerable to O, although the differences between different subgroups were insignificant. The dose-response curve showed that the mortality of cardiovascular disease increased with the increase of O. The increase in O concentration of atmospheric can increase the daily mortality of cardiovascular diseases in Jiangsu, China.
为了探索臭氧（O）和 PM 对中国江苏省所有城市每日心血管疾病死亡率的急性健康影响。从 2015 年 1 月 1 日至 2017 年 12 月 31 日，收集了臭氧（最大 8 小时平均值）、细颗粒物（PM）、气象数据（包括温度和相对湿度）和每日心血管疾病死亡率数据，来自中国江苏省的 13 个城市。时间序列模型与泊松分布相关联，用于估计 O 与每日心血管疾病死亡率之间的相关性，同时调整了 PM 和其他污染物的影响。首先，我们评估了 O 对江苏省每个城市心血管死亡率的急性影响，然后通过荟萃分析综合了 O 对心血管疾病死亡率的影响。单污染物模型表明，O 在不同城市的急性健康影响差异很大。在结合了 13 个城市的影响后，心血管疾病死亡率增加了 0.983%（95%CI：0.588-1.377%），每增加 10μg/m³ O。O 对 3 天移动平均值浓度（滞后 0-3）的影响最大。在调整 PMNO、SO 和 CO 后，在多城市水平上的结果仍然具有统计学意义。研究发现 O 对女性的影响更大；老年人口易受影响，高教育群体对 O 更易受影响，尽管不同亚组之间的差异不显著。剂量反应曲线表明，心血管疾病的死亡率随着 O 的增加而增加。大气中 O 浓度的增加会增加中国江苏省每日心血管疾病的死亡率。
