Wang Tianyun, Wang Junlong, Sun Li, Deng Ye, Xiang Yuting, Wang Yuting, Chen Jiamei, Peng Wen, Cui Yuanyao, He Miao
Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Physical Factors and Health, School of Public Health, Ministry of Education, China Medical University, Shenyang 110122, China.
Liaoning Provincial Center for Disease Control and Prevention, Shenyang 110005, China.
Toxics. 2025 Feb 28;13(3):184. doi: 10.3390/toxics13030184.
Ozone pollution has increased alongside China's economic development, contributing to public health issues such as cardiovascular and cerebrovascular diseases. At present, the problem of an aging population is aggravated, which is worth more attention in terms of the health problems of elderly people.
This study employed a distributional lag nonlinear model (DLNM) with Poisson regression to analyze the impact of ozone on cardiovascular and cerebrovascular disease mortality among the elderly in Shenyang, China, from 2014 to 2018. In addition, a time-series generalized additive regression model (GAM) was used to analyze the joint effect between PM and ozone.
We found a positive correlation between ozone and mortality from cardiovascular and cerebrovascular diseases in the elderly. The maximum relative risk (RR) of mortality from cardiovascular and cerebrovascular diseases for every 10 μg/m increase in ozone was 1.005 (95% CI: 1.002-1.008). Males (RR: 1.018, 95% CI: 1.007-1.030), individuals in unconventional marital status (RR: 1.024, 95% CI: 1.011-1.038), and outdoor workers (RR: 1.017, 95% CI: 1.002-1.031) were more vulnerable to ozone pollution. This study did not find significant differences in the impact of ozone pollution on cardiovascular and cerebrovascular disease mortality risks among different educational groups. Additionally, a joint effect between ozone and PM was observed.
This study confirms that ozone exposure is positively associated with increased mortality from cardiovascular and cerebrovascular diseases. It emphasizes the joint effect of ozone and PM in exacerbating cardiovascular and cerebrovascular disease mortality.
随着中国经济发展，臭氧污染加剧，引发了心血管和脑血管疾病等公共卫生问题。目前，人口老龄化问题加剧，老年人的健康问题值得更多关注。
本研究采用泊松回归分布滞后非线性模型（DLNM）分析2014年至2018年中国沈阳臭氧对老年人心血管和脑血管疾病死亡率的影响。此外，使用时间序列广义相加回归模型（GAM）分析PM与臭氧之间的联合效应。
我们发现臭氧与老年人心血管和脑血管疾病死亡率之间呈正相关。臭氧每增加10μg/m³，心血管和脑血管疾病死亡率的最大相对风险（RR）为1.005（95%CI：1.002 - 1.008）。男性（RR：1.018，95%CI：1.007 - 1.030）、非传统婚姻状况个体（RR：1.024，95%CI：1.011 - 1.038）和户外工作者（RR：1.017，95%CI：1.002 - 1.031）更容易受到臭氧污染影响。本研究未发现臭氧污染对不同教育程度人群心血管和脑血管疾病死亡风险的影响存在显著差异。此外，观察到臭氧与PM之间存在联合效应。
本研究证实，臭氧暴露与心血管和脑血管疾病死亡率增加呈正相关。强调了臭氧与PM在加剧心血管和脑血管疾病死亡率方面的联合效应。
