Shimizu M, Yano E
Mutat Res. 1986 Apr-May;170(1-2):11-22. doi: 10.1016/0165-1218(86)90077-7.
The mutagenicities of 37 mono-nitrobenzene derivatives, i.e. the ortho, meta, and para isomers of nitrotoluene, nitrophenol, nitroaniline, nitroanisole, nitrobenzaldehyde, nitrobenzyl chloride, nitrobenzonitrile, nitroacetophenone, nitrophenetol, nitrobenzoic acid, nitrophenylacetic acid, and nitrocinnamic acid and p-nitrothiophenol, were tested in the Ames test and rec assay. The rec assay gave more positive results than the Ames test. The para-substituted nitrobenzene derivatives were always positive in the rec assay as were all but 2 in the Ames test, while 5 out of 12 ortho and meta derivatives were mutagenic in the Ames test. The results of the present study, combined with those of the previous study, are discussed with special reference to the structure-mutagenicity relationships.
测试了37种单硝基苯衍生物的致突变性，即硝基甲苯、硝基苯酚、硝基苯胺、硝基苯甲醚、硝基苯甲醛、硝基苄基氯、硝基苯腈、硝基苯乙酮、硝基苯乙醚、硝基苯甲酸、硝基苯乙酸、硝基肉桂酸的邻、间、对异构体以及对硝基硫酚，采用Ames试验和rec试验进行测试。rec试验比Ames试验得到更多阳性结果。对位取代的硝基苯衍生物在rec试验中总是呈阳性，在Ames试验中除2种外也都呈阳性，而在Ames试验中12种邻位和间位衍生物中有5种具有致突变性。结合先前研究的结果，特别参考结构-致突变性的关系，对本研究的结果进行了讨论。
