在哈夫曼离子存在下透明质酸溶液的行为：光散射、黏度和表面张力研究。

The behaviour of hyaluronan solutions in the presence of Hofmeister ions: A light scattering, viscometry and surface tension study.

机构信息

Tomas Bata University in Zlín, Faculty of Technology, Department of Physics and Material Engineering, nám. T.G. Masaryka 5555, 760 01 Zlín, Czech Republic; Centre of Polymer Systems, Tomas Bata University in Zlín, nám. T.G. Masaryka 5555, 760 01 Zlín, Czech Republic.

Centre of Polymer Systems, Tomas Bata University in Zlín, nám. T.G. Masaryka 5555, 760 01 Zlín, Czech Republic; Tomas Bata University in Zlín, Faculty of Technology, Department of Fat, Surfactant and Cosmetics Technology, nám. T.G. Masaryka 5555, 760 01 Zlín, Czech Republic.

出版信息

Carbohydr Polym. 2019 May 15;212:395-402. doi: 10.1016/j.carbpol.2019.02.032. Epub 2019 Feb 19.

DOI:10.1016/j.carbpol.2019.02.032

PMID:30832872

Abstract

Dynamic light scattering (DLS), viscosity and surface tension (SFT) measurements were used to characterize influence of salts containing ions of Hofmeister series (NaSO, (NH)SO, NaSCN, NHSCN and NaCl) on the behaviour of hyaluronan in diluted solutions at a temperature range of 15-45 °C. The results of the study showed that chaotropic and kosmotropic ions notably influenced the folding and unfolding of hyaluronan coils due to interactions between a respective ion and hydrophilic or hydrophobic patches present in the backbone of the polymer chains. This was mainly proved by viscosity and light scattering measurements. The temperature dependence of the hydrodynamic diameter of the hyaluronan coil determined by DLS demonstrated that combinations of chaotropic and kosmotropic ions in one salt (NaCl, NaSCN and (HN)SO) can stabilize the size of the coil in a wide range of temperatures. Tensiometry measurements indicated that certain types of ions present in the solution caused an unfolding of the hyaluronan coils, leading to a decrease of SFT.

摘要

动态光散射 (DLS)、粘度和表面张力 (SFT) 测量用于表征包含侯氏盐系列离子 (NaSO、(NH)SO、NaSCN、NHSCN 和 NaCl) 的盐对透明质酸在 15-45°C 温度范围内稀溶液中行为的影响。研究结果表明，由于相应离子与聚合物链骨架中存在的亲水性或疏水性斑块之间的相互作用，离液剂和等渗剂离子显著影响透明质酸线圈的折叠和展开。这主要通过粘度和光散射测量得到证明。DLS 测定的透明质酸线圈水动力直径的温度依赖性表明，一种盐（NaCl、NaSCN 和 (HN)SO）中离液剂和等渗剂离子的组合可以在很宽的温度范围内稳定线圈的大小。张力测量表明，溶液中存在的某些类型的离子导致透明质酸线圈展开，导致 SFT 降低。