Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, 760 01 Zlín, Czech Republic.
Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic.
Int J Mol Sci. 2021 Feb 16;22(4):1932. doi: 10.3390/ijms22041932.
Tracer diffusion coefficients obtained from the Taylor dispersion technique at 25.0 °C were measured to study the influence of sodium, ammonium and magnesium salts at 0.01 and 0.1 mol dm on the transport behavior of sodium hyaluronate (NaHy, 0.1%). The selection of these salts was based on their position in Hofmeister series, which describe the specific influence of different ions (cations and anions) on some physicochemical properties of a system that can be interpreted as a salting-in or salting-out effect. In our case, in general, an increase in the ionic strength (i.e., concentrations at 0.01 mol dm) led to a significant decrease in the limiting diffusion coefficient of the NaHy 0.1%, indicating, in those circumstances, the presence of salting-in effects. However, the opposite effect (salting-out) was verified with the increase in concentration of some salts, mainly for NHSCN at 0.1 mol dm. In this particular salt, the cation is weakly hydrated and, consequently, its presence does not favor interactions between NaHy and water molecules, promoting, in those circumstances, less resistance to the movement of NaHy and thus to the increase of its diffusion (19%). These data, complemented by viscosity measurements, permit us to have a better understanding about the effect of these salts on the transport behaviour of NaHy.
在 25.0°C 下，通过泰勒分散技术获得的示踪扩散系数用于研究钠离子、铵离子和镁离子盐在 0.01 和 0.1 mol dm 浓度下对透明质酸钠（NaHy，0.1%）传输行为的影响。选择这些盐是基于它们在豪夫迈斯特序列中的位置，该序列描述了不同离子（阳离子和阴离子）对系统某些物理化学性质的具体影响，可以解释为盐溶或盐析效应。在我们的案例中，一般来说，离子强度（即 0.01 mol dm 浓度）的增加导致 NaHy 0.1%的限制扩散系数显著降低，表明在这些情况下存在盐溶效应。然而，随着某些盐浓度的增加，出现了相反的效应（盐析），主要是在 NHSCN 浓度为 0.1 mol dm 时。在这种特殊的盐中，阳离子的水合作用较弱，因此其存在不利于 NaHy 与水分子之间的相互作用，从而在这些情况下，对 NaHy 运动的阻力较小，因此扩散增加（19%）。这些数据，结合粘度测量结果，使我们能够更好地理解这些盐对 NaHy 传输行为的影响。
