Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Dana-Farber Cancer Institute, 450 Brookline Ave, Room LW503, Boston, MA 02215, USA.
Department of Medical Oncology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
Hematol Oncol Clin North Am. 2019 Apr;33(2):261-274. doi: 10.1016/j.hoc.2018.12.004. Epub 2019 Jan 28.
The processes controlled by cytokines may be co-opted by pathologic states, contributing to processes that threaten host well-being. A nuanced understanding of this immense web of chemical communications will allow us to understand the mechanisms and limitations of current therapies and to enhance their therapeutic benefits while minimizing their toxicities. This article reviews the current state of cytokine science in malignancy, focusing on agents that are approved for therapy or are in late-stage development. Promising new directions, including novel engineered.
细胞因子所控制的过程可能被病理状态所利用，从而导致威胁宿主健康的过程。对这种庞大的化学通讯网络的细致理解，将使我们能够了解当前治疗方法的机制和局限性，并提高它们的治疗效益，同时将其毒性降至最低。本文综述了恶性肿瘤中细胞因子科学的现状，重点介绍了已批准用于治疗或处于后期开发阶段的药物。包括新型工程化.
