非动脉炎性前部缺血性视神经病变中的系统性氧化应激。
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy.
机构信息
Department of Ophtalmology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Department of Ophthalmology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
出版信息
Eye (Lond). 2019 Jul;33(7):1140-1144. doi: 10.1038/s41433-019-0388-0. Epub 2019 Mar 4.
PURPOSE
To investigate whether the serum total oxidant status (TOS), total antioxidant status (TAS), advanced oxidation protein products (AOPP), and thiol parameters could play a role in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NA-AION).
METHODS
In this study, 18 newly diagnosed NA-AION patients and 17 healthy subjects (control group) were included. Serum plasma TOS and TAS, AOPP, and thiol parameters were measured by spectrophotometric method and the results were compared.
RESULTS
Mean age of the patients and the controls were 60.8 ± 8.4 and 61.9 ± 9.4 years, respectively (p = 0.729). There were no significant differences between the patients and the control group with regard to the values of TAS, TOS, AOPP, and thiol (p = 0.869, p = 0.863, p = 0.040, p = 0.314; respectively). There was a positive correlation between TOS and thiol (p = 0.002, r = 0.681).
CONCLUSION
We found no significant relationship between systemic oxidative parameters and NA-AION. However, this study should be accepted as a pilot investigation and needs to be validated.
目的
探讨血清总氧化剂状态（TOS）、总抗氧化状态（TAS）、晚期氧化蛋白产物（AOPP）和巯基参数是否在非动脉炎性前部缺血性视神经病变（NA-AION）发病机制中起作用。
方法
本研究纳入了 18 例新诊断的 NA-AION 患者和 17 例健康受试者（对照组）。采用分光光度法测定血清血浆 TOS 和 TAS、AOPP 和巯基参数，并比较结果。
结果
患者和对照组的平均年龄分别为 60.8±8.4 岁和 61.9±9.4 岁（p=0.729）。患者与对照组之间 TAS、TOS、AOPP 和巯基的差异无统计学意义（p=0.869、p=0.863、p=0.040、p=0.314）。TOS 与巯基之间存在正相关（p=0.002，r=0.681）。
结论
我们未发现全身氧化参数与 NA-AION 之间存在显著关系。然而，这项研究应被视为初步研究，需要进一步验证。
Zotero 插件