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人源微小RNA-let-7d-5p通过靶向PR结构域蛋白5促进胃癌进展。

Hsa-let-7d-5p Promotes Gastric Cancer Progression by Targeting PRDM5.

作者信息

Gao Xiang, Liu Huiqi, Wang Rong, Huang Mingyu, Wu Qiong, Wang Yang, Zhang Wei, Liu Yongnian

机构信息

Research Centre for High Altitude Medicine, Qinghai University, Xining, Qinghai 810001, China.

The Key Laboratory of Plateau Medicine Ministry of Education, Xining, Qinghai 810001, China.

出版信息

J Oncol. 2022 Jul 7;2022:2700651. doi: 10.1155/2022/2700651. eCollection 2022.

DOI:10.1155/2022/2700651
PMID:35847370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9283079/
Abstract

Gastric cancer (GC) is a common malignant tumor in the digestive system and a significant health burden worldwide. In this study, we found that hsa-let-7d-5p was upregulated in GC cells, promoted GC cell proliferation, migration, and invasion, and reduced apoptosis. Moreover, we found that the expression of PRDM5 (PR domain protein 5) was downregulated in GC cells and upregulated in GC cells treated with hsa-let-7d-5p inhibitor. Further investigation showed that hsa-let-7d-5p was the target of PRDM5, and the functions of hsa-let-7d-5p on GC progression were rescued by PRDM5 overexpression in GC cells. Collectively, our findings suggested that hsa-let-7d-5p promoted the development of GC by targeting PRDM5, indicating that hsa-let-7d-5p could be a promising therapeutic molecule for the treatment of gastric cancer.

摘要

胃癌（GC）是消化系统常见的恶性肿瘤，也是全球重大的健康负担。在本研究中，我们发现hsa-let-7d-5p在GC细胞中上调，促进GC细胞增殖、迁移和侵袭，并减少细胞凋亡。此外，我们发现PRDM5（PR结构域蛋白5）的表达在GC细胞中下调，而在用hsa-let-7d-5p抑制剂处理的GC细胞中上调。进一步研究表明，hsa-let-7d-5p是PRDM5的靶点，并且在GC细胞中过表达PRDM5可挽救hsa-let-7d-5p对GC进展的作用。总体而言，我们的研究结果表明hsa-let-7d-5p通过靶向PRDM5促进GC的发展，这表明hsa-let-7d-5p可能是治疗胃癌的有前景的治疗分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/6597ed1edad5/JO2022-2700651.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/420bf2649afb/JO2022-2700651.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/980b1fb38607/JO2022-2700651.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/71cec85940e6/JO2022-2700651.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/b66de7efe384/JO2022-2700651.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/6597ed1edad5/JO2022-2700651.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/420bf2649afb/JO2022-2700651.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/980b1fb38607/JO2022-2700651.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/71cec85940e6/JO2022-2700651.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/b66de7efe384/JO2022-2700651.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa39/9283079/6597ed1edad5/JO2022-2700651.005.jpg

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