Kamjam Manita, Sivalingam Periyasamy, Deng Zinxin, Hong Kui
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical SciencesWuhan, China.
Front Microbiol. 2017 May 1;8:760. doi: 10.3389/fmicb.2017.00760. eCollection 2017.
Deep sea is a unique and extreme environment. It is a hot spot for hunting marine actinomycetes resources and secondary metabolites. The novel deep sea actinomycete species reported from 2006 to 2016 including 21 species under 13 genera with the maximum number from , followed by and , and one novel species for the other 9 genera. Eight genera of actinomycetes were reported to produce secondary metabolites, among which is the richest producer. Most of the compounds produced by the deep sea actinomycetes presented antimicrobial and anti-cancer cell activities. Gene clusters related to biosynthesis of desotamide, heronamide, and lobophorin have been identified from the deep sea derived .
深海是一个独特的极端环境。它是寻找海洋放线菌资源和次生代谢产物的热点区域。2006年至2016年报道的新型深海放线菌物种包括13个属的21个物种，其中属的数量最多，其次是属和属，其他9个属各有一个新物种。据报道，有8个属的放线菌能产生次生代谢产物，其中属产生的次生代谢产物最为丰富。深海放线菌产生的大多数化合物具有抗菌和抗癌细胞活性。已从深海来源的中鉴定出与去索酰胺、苍鹭酰胺和洛波佛林生物合成相关的基因簇。
