临床健康人群的血清铁代谢变量
Serum Iron Metabolism Variables in Clinically Healthy Persons.
作者信息
Penkova Mariana, Ivanova Nadezhda
机构信息
Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria.
出版信息
Open Access Maced J Med Sci. 2019 Feb 7;7(3):318-321. doi: 10.3889/oamjms.2019.083. eCollection 2019 Feb 15.
BACKGROUND
In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism.
MATERIAL
Subject to the testing were 60 healthy volunteers who took part in clinical trials.
METHODS
Case histories, physical check-up and demographic data including people's heights and weights, laboratory studies and tests using medical equipment.
RESULTS
None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin.
CONCLUSION
In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation.
背景
在健康个体中，由于缺乏从体内排泄过量铁的生理途径，铁的获取、转运和储存是严格调控的过程。肝脏、十二指肠和骨髓参与铁代谢的调节。
材料
接受测试的是60名参与临床试验的健康志愿者。
方法
病历、体格检查以及包括身高和体重在内的人口统计学数据、实验室研究和使用医疗设备进行的检测。
结果
除了铁调素外，未报告任何健康个体的铁代谢血清标志物检测结果偏离参考值。
结论
在健康个体中，铁水平与铁结合能力之间仅存在正相关，以及铁调素血清水平与转铁蛋白饱和度之间存在反馈关系。
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