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Front Chem. 2019 Feb 18;7:71. doi: 10.3389/fchem.2019.00071. eCollection 2019.
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MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.阿尔茨海默病背景下的MTDL设计策略：从脂分泌到美金刚胺及其他。
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Rationally designed multitarget anti-HIV agents.理性设计的抗 HIV 多靶位药物。
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1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer's Disease.1,3,5-三嗪：一种用于治疗阿尔茨海默病新型药物的有前景的分子骨架。
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A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics.阿尔茨海默病研究的最新进展以及利用网络生物学方法确定诊断和治疗优先级的综述。
Diagnostics (Basel). 2022 Nov 28;12(12):2975. doi: 10.3390/diagnostics12122975.
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Design of Anti-infectious Agents from Lawsone in a Three-Component Reaction with Aldehydes and Isocyanides.基于胡桃醌与醛和异腈的三组分反应设计抗感染剂
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Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease.新型香豆素 - 吡啶杂化物作为针对阿尔茨海默病症状的强效多靶点导向配体
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本文引用的文献

1
A perspective on multi-target drug discovery and design for complex diseases.复杂疾病多靶点药物发现与设计的视角
Clin Transl Med. 2018 Jan 17;7(1):3. doi: 10.1186/s40169-017-0181-2.
2
Network pharmacology: the next paradigm in drug discovery.网络药理学：药物研发的下一个范式
Nat Chem Biol. 2008 Nov;4(11):682-90. doi: 10.1038/nchembio.118.

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation.

作者信息

Alcaro Stefano, Bolognesi Maria Laura, García-Sosa Alfonso T, Rapposelli Simona

机构信息

Net4Science Academic Spin-Off, Università "Magna Græcia" di Catanzaro, Campus Universitario "S. Venuta", Catanzaro, Italy.

Department of Pharmacy and Biotechnology, Università di Bologna, Bologna, Italy.

出版信息

Front Chem. 2019 Feb 18;7:71. doi: 10.3389/fchem.2019.00071. eCollection 2019.

DOI:10.3389/fchem.2019.00071
PMID:30834243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6387964/
Abstract
摘要