Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation.
作者信息
Alcaro Stefano, Bolognesi Maria Laura, García-Sosa Alfonso T, Rapposelli Simona
机构信息
Net4Science Academic Spin-Off, Università "Magna Græcia" di Catanzaro, Campus Universitario "S. Venuta", Catanzaro, Italy.
Department of Pharmacy and Biotechnology, Università di Bologna, Bologna, Italy.
出版信息
Front Chem. 2019 Feb 18;7:71. doi: 10.3389/fchem.2019.00071. eCollection 2019.
Abstract
摘要
相似文献
1
Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation.社论：多靶点导向配体（MTDL）作为药物研发中具有挑战性的研究工具：从设计到药理评估
Front Chem. 2019 Feb 18;7:71. doi: 10.3389/fchem.2019.00071. eCollection 2019.
2
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.阿尔茨海默病背景下的MTDL设计策略：从脂分泌到美金刚胺及其他。
Curr Pharm Des. 2009;15(6):601-13. doi: 10.2174/138161209787315585.
3
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.作为酶抑制剂和受体配体的多靶点导向配体。
Eur J Med Chem. 2019 Oct 15;180:690-706. doi: 10.1016/j.ejmech.2019.07.040. Epub 2019 Jul 12.
4
Applications of Multi-Target Computer-Aided Methodologies in Molecular Design of CNS Drugs.多靶标计算机辅助方法在 CNS 药物分子设计中的应用。
Curr Med Chem. 2018;25(39):5293-5314. doi: 10.2174/0929867324666170920154111.
5
Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer's Disease: An Update.多靶点导向药物作为阿尔茨海默病药物设计的现代方法：最新进展。
Curr Med Chem. 2018;25(29):3491-3525. doi: 10.2174/0929867325666180111101843.
6
Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies.中枢神经系统疾病的药物设计：使用化学信息学、3D-QSAR和虚拟筛选方法对化合物进行多药理学分析。
Front Neurosci. 2016 Jun 10;10:265. doi: 10.3389/fnins.2016.00265. eCollection 2016.
7
The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing.Mu.Ta.Lig.化学数据库：一个用于多靶点配体识别和化合物重新利用的社区填充分子数据库。
Front Chem. 2018 Apr 19;6:130. doi: 10.3389/fchem.2018.00130. eCollection 2018.
8
Rationally designed multitarget anti-HIV agents.理性设计的抗 HIV 多靶位药物。
Curr Med Chem. 2013;20(13):1743-58. doi: 10.2174/0929867311320130011.
9
CADD Modeling of Multi-Target Drugs Against Alzheimer's Disease.针对阿尔茨海默病的多靶点药物的计算机辅助药物设计建模
Curr Drug Targets. 2017;18(5):522-533. doi: 10.2174/1389450116666150907104855.
10
In-silico approaches to multi-target drug discovery : computer aided multi-target drug design, multi-target virtual screening.计算机辅助多靶标药物设计、多靶标虚拟筛选的计算方法在多靶标药物发现中的应用
Pharm Res. 2010 May;27(5):739-49. doi: 10.1007/s11095-010-0065-2. Epub 2010 Mar 11.
引用本文的文献
1
Editorial: Multi-target drug discovery and design for complex health disorders.社论：针对复杂健康疾病的多靶点药物发现与设计
Front Pharmacol. 2025 Jun 13;16:1633600. doi: 10.3389/fphar.2025.1633600. eCollection 2025.
2
1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer's Disease.1,3,5-三嗪：一种用于治疗阿尔茨海默病新型药物的有前景的分子骨架。
Int J Mol Sci. 2025 Jan 21;26(3):882. doi: 10.3390/ijms26030882.
3
Pioneering first-in-class HDAC-ROCK inhibitors as potential multitarget anticancer agents.开创性的一流HDAC-ROCK抑制剂作为潜在的多靶点抗癌药物。
Future Med Chem. 2025 Feb;17(4):393-407. doi: 10.1080/17568919.2025.2459589. Epub 2025 Jan 30.
4
Exploration of novel triazolo-thiadiazine hybrids of deferasirox as multi-target-directed anti-neuroinflammatory agents with structure-activity relationship (SAR): a new treatment opportunity for Alzheimer's disease.探索去铁胺新型三唑并噻二嗪杂化物作为具有构效关系（SAR）的多靶点抗神经炎症药物：阿尔茨海默病的新治疗机遇。
RSC Adv. 2025 Jan 2;15(1):101-118. doi: 10.1039/d4ra06916a.
5
Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents.多靶点药物在癌症治疗中的潜力和未来展望：新一代抗癌药物。
Cell Commun Signal. 2024 Apr 15;22(1):228. doi: 10.1186/s12964-024-01607-9.
6
Exploring the potential of multi-target-directed ligands for tuberculosis treatment.探索多靶点导向配体在结核病治疗中的潜力。
Ther Adv Infect Dis. 2023 Jul 15;10:20499361231188039. doi: 10.1177/20499361231188039. eCollection 2023 Jan-Dec.
7
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.鉴定新型 4-(6-氧代哒嗪-1-基)苯磺酰胺类化合物作为多靶点抗炎剂，靶向碳酸酐酶、COX-2 和 5-LOX 酶：合成、生物学评价和建模见解。
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407. doi: 10.1080/14756366.2023.2201407.
8
A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics.阿尔茨海默病研究的最新进展以及利用网络生物学方法确定诊断和治疗优先级的综述。
Diagnostics (Basel). 2022 Nov 28;12(12):2975. doi: 10.3390/diagnostics12122975.
9
Design of Anti-infectious Agents from Lawsone in a Three-Component Reaction with Aldehydes and Isocyanides.基于胡桃醌与醛和异腈的三组分反应设计抗感染剂
ACS Omega. 2022 Oct 3;7(40):35635-35655. doi: 10.1021/acsomega.2c03421. eCollection 2022 Oct 11.
10
Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease.新型香豆素 - 吡啶杂化物作为针对阿尔茨海默病症状的强效多靶点导向配体
Front Chem. 2022 Jun 30;10:895483. doi: 10.3389/fchem.2022.895483. eCollection 2022.
本文引用的文献
1
A perspective on multi-target drug discovery and design for complex diseases.复杂疾病多靶点药物发现与设计的视角
Clin Transl Med. 2018 Jan 17;7(1):3. doi: 10.1186/s40169-017-0181-2.
2
Network pharmacology: the next paradigm in drug discovery.网络药理学：药物研发的下一个范式
Nat Chem Biol. 2008 Nov;4(11):682-90. doi: 10.1038/nchembio.118.
Zotero 插件