Turk J Med Sci. 2019 Apr 18;49(2):525-530. doi: 10.3906/sag-1811-41.
BACKGROUND/AIM: Our research focused on the identification of easily available and sensitive markers for early prediction of acute kidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR in kidney transplant patients.
The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24–44) years] were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR.
A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to the controls (P < 0.001). NLR levels over 2.5 [95% CI: 54.88 (9.96–302.3), P < 0.001] were significantly associated with AR in univariate analysis. The NLR levels were the only significant factor associated with AR in multivariate models, in model 1 (adjusted by age and sex) [95% CI: 114 (11.1–1175), P < 0.001], and in model 2 (adjusted by steroid dosage, uric acid, and NLR) [95% CI: 4.60 (1.59–29.3), P = 0.004].
Our data showed that higher NLR values (>2.5) are associated with AR in kidney transplant patients, leading to the conclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.
背景/目的：我们的研究重点是确定易于获得且敏感的标志物，以便早期预测急性肾移植排斥反应（AR）。我们旨在研究中性粒细胞与淋巴细胞比值（NLR）与肾移植患者 AR 之间的关系。
回顾性评估了 51 例肾移植患者的病历[12 名女性/39 名男性；中位年龄 32（IQR：24-44）岁]。我们将 NLR ＞2.5 定义为高 NLR。
共评估了 22 例经活检证实的 AR 患者和 29 例对照者。AR 组的 NLR 高于对照组（P＜0.001）。NLR 水平超过 2.5[95%CI：54.88（9.96-302.3），P＜0.001]在单变量分析中与 AR 显著相关。在多变量模型中，NLR 水平是与 AR 唯一相关的显著因素，在模型 1（按年龄和性别调整）[95%CI：114（11.1-1175），P＜0.001]和模型 2（按类固醇剂量、尿酸和 NLR 调整）[95%CI：4.60（1.59-29.3），P=0.004]中。
我们的数据表明，较高的 NLR 值（＞2.5）与肾移植患者的 AR 相关，这表明 NLR 可能是该患者人群中检测 AR 的一种易于获得且有用的标志物。
