从大苞猕猴桃的叶和嫩枝提取物中分离得到的α-葡萄糖苷酶抑制剂类黄酮和环氧庚酮。
α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis.
机构信息
School of Chemistry and Molecular Biosciences , University of Wollongong , Wollongong , New South Wales 2522 , Australia.
出版信息
J Nat Prod. 2019 Apr 26;82(4):741-747. doi: 10.1021/acs.jnatprod.8b00581. Epub 2019 Mar 5.
Four new flavonoids (1-4), a new benzyl benzoate derivative (5), five new oxepinones (6-10), and 14 known compounds (11-24) were isolated from the leaf and twig extracts of Desmos cochinchinensis. Their structures were established by spectroscopic methods. The structure of 1 was also confirmed by X-ray diffraction data. The absolute configurations of 3, 4, and 6-10 were determined from comparisons of their ECD spectra with those of relevant reported compounds. Compounds 1, 2, 6, 8, 10, 12-15, and 17 showed α-glucosidase inhibitory activities with IC values ranging from 0.2 to 4.9 μM.
从 Desmos cochinchinensis 的叶和嫩枝提取物中分离得到四个新的类黄酮（1-4）、一个新的苯甲酸苄酯衍生物（5）、五个新的环氧庚酮（6-10）和 14 个已知化合物（11-24）。通过光谱方法确定了它们的结构。1 的结构也通过 X 射线衍射数据得到证实。通过比较它们的 ECD 光谱与相关报道化合物的 ECD 光谱，确定了 3、4 和 6-10 的绝对构型。化合物 1、2、6、8、10、12-15 和 17 对α-葡萄糖苷酶表现出抑制活性，IC 值范围为 0.2-4.9 μM。
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