Department of Chemistry, Institute of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Department of Applied Biochemistry, Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Prog Chem Org Nat Prod. 2021;116:211-261. doi: 10.1007/978-3-030-80560-9_5.
The combination of traditional knowledge of medicinal plants with scientific rationale has yielded positive results in recent years. Bioactive compounds isolated from herbaceous plants have long been used as drugs that benefit human health, as well as providing useful compounds for drug development lead compound optimization. This chapter aims to provide a systematic overview of the structural types of Desmos secondary metabolites, along with their biological potential. Various chromatographic and spectroscopic methods have been utilized for isolating, purifying, and elucidating the structures of compounds from Desmos species. From 1982 to the present time, more than 200 metabolites have been isolated from members of this genus. Desmos spp. constituents include terpenoids, phytosterols, polyoxygenated cyclohexanes and cyclohexenes, oxepinones, fatty acids, with flavonoids, alkaloids, and miscellaneous phenols being the predominant compounds. The essential oils of Desmos species have also been investigated. Both crude plant extracts and isolated compounds from this genus have been evaluated for their biological activities. Desmos constituents have been found to exhibit cytotoxic, antimicrobial, antioxidative, anti-inflammatory, and aromatase and NFAT transcriptive inhibition effects.
近年来，将药用植物的传统知识与科学原理相结合，取得了积极的成果。从草本植物中分离出的生物活性化合物长期以来一直被用作有益于人类健康的药物，同时也为药物开发提供了有用的先导化合物优化。本章旨在对野牡丹科次生代谢产物的结构类型及其生物潜能进行系统概述。已经使用了各种色谱和光谱方法来从 Desmos 属中分离、纯化和阐明化合物的结构。自 1982 年至今，从该属的成员中分离出了 200 多种代谢物。Desmos spp. 的成分包括萜类化合物、甾醇、多氧化环己烷和环己烯、氧杂环庚酮、脂肪酸，其中黄酮类、生物碱和各种酚类化合物是主要化合物。野牡丹科植物的精油也进行了研究。该属的粗植物提取物和分离化合物都已评估了其生物活性。已经发现 Desmos 的成分具有细胞毒性、抗菌、抗氧化、抗炎和芳香酶及 NFAT 转录抑制作用。
