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Dasymaschalolactams A-E,来自. 小枝提取物的 Aristolactams。

Dasymaschalolactams A-E, Aristolactams from a Twig Extract of .

机构信息

Department of Chemistry and Department of Earth, Ocean & Atmospheric Sciences , University of British Columbia , 2036 Main Mall , Vancouver , BC , Canada V6T 1Z1.

School of Chemistry and Molecular Bioscience , University of Wollongong , Wollongong , New South Wales 2522 , Australia.

出版信息

J Nat Prod. 2019 Nov 22;82(11):3176-3180. doi: 10.1021/acs.jnatprod.9b00506. Epub 2019 Oct 29.

Abstract

Five new aristolactam alkaloids (-), dasymaschalolactams A-E, and the first isolation of dasymaschalolactone () as a natural product, together with 19 known compounds (- and -) were isolated from the twig extract of . Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. Compounds and showed α-glucosidase inhibitory activities with IC values of 4.5 and 24.7 μM, respectively.

摘要

从. 的嫩枝提取物中分离得到了 5 个新的吖啶酮生物碱(-)、dasymaschalolactams A-E,以及 dasymaschalolactone()作为天然产物的首次分离,以及 19 个已知化合物(-和-)。通过光谱方法以及与文献的比较阐明了它们的结构。化合物和表现出α-葡萄糖苷酶抑制活性,IC 值分别为 4.5 和 24.7 μM。

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