来自[具体来源未给出]的生物碱和苯乙烯基内酯及其生物活性。
Alkaloids and Styryl Lactones from and Their Biological Activities.
作者信息
Champakam Sorraya, Patrick Brian O, Injan Natcha, Nokbin Somkiat, Cheenpracha Sarot, Loh Zi Han, Maneerat Tharakorn, Winyayong Panom, Promnart Phunrawie, Mah Siau Hui, Andersen Raymond J, Laphookhieo Surat
机构信息
Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
出版信息
J Nat Prod. 2025 Jul 25;88(7):1549-1556. doi: 10.1021/acs.jnatprod.4c00933. Epub 2024 Nov 7.
Phytochemical investigations of the twig and leaf extracts of resulted in the isolation and identification of two new alkaloids, goniotortiline () and goniotortilactam (), three new styryl lactone derivatives, goniotortilactone () and goniotortilols A () and B (), and 25 known compounds. Their structures were elucidated by spectroscopic methods and HRESITOFMS data. Compounds , , , , , and inhibited nitric oxide (NO) production with IC values ranging from 8.7 ± 0.1 to 17 ± 1 μM, revealing stronger effects than the standard drug, dexamethasone (IC 16.9 ± 2.2 μM), and compound possessed the most potent NO production inhibition. Compounds and demonstrated notable efficacy in enhancing glucose consumption with IC values of 77 ± 4 and 66 ± 4 μM, respectively, while their glucose uptakes were 1.7- and 2-fold, respectively.
对[植物名称]嫩枝和叶片提取物进行的植物化学研究，导致分离并鉴定出两种新生物碱，戈尼奥托替林（）和戈尼奥托替内酰胺（），三种新的苯乙烯基内酯衍生物，戈尼奥托替内酯（）和戈尼奥托替醇A（）以及B（），还有25种已知化合物。通过光谱方法和高分辨电喷雾电离飞行时间质谱（HRESITOFMS）数据阐明了它们的结构。化合物、、、、、和抑制一氧化氮（NO）生成，其半数抑制浓度（IC）值范围为8.7±0.1至17±1μM，显示出比标准药物地塞米松（IC 16.9±2.2μM）更强的效果，并且化合物具有最有效的NO生成抑制作用。化合物和在增强葡萄糖消耗方面表现出显著功效，其IC值分别为77±4和66±4μM，而它们的葡萄糖摄取量分别为1.7倍和2倍。
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